Four patients with cutaneous metastases from medullary thyroid cancer

Libero Santarpia, Adel K. El-Naggar, Steven I. Sherman, Sharon R. Hymes, Robert F. Gagel, Stephanie Shaw, Nicholas J. Sarlis

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Abstract

Cutaneous metastasis from thyroid cancer, especially medullary thyroid cancer (MTC) is rare. We report four patients with cutaneous metastases from sporadic MTC, three women and one man, aged 50 to 69 years. They presented different cutaneous lesions phenotypes. The first patient had a remote history of MTC and initial presentation of the recurrence was a rapidly progressing cutaneous lesion; on subsequent disease staging, widely metastatic disease was discovered. The other three patients developed cutaneous metastases in the presence of known distant metastases, indicating systemic spread of thyroid cancer. Definitive diagnosis of cutaneous metastases of MTC was made on biopsy of the lesions with cells that stained positive for neuroendocrine markers. Accurate diagnosis of cutaneous metastasis from MTC is important because it is a negative prognostic factor indicative of multisystemic disease. Thus, MTC metastases should be included in the differential diagnosis of erythematous maculopapular eruptions and nodular lesions of the skin, especially when these metastases occur in the upper part of the body and if the patient has a history of MTC. The appearing of cutaneous metastasis is a negative prognostic factor since all the patients here described died within one year from the diagnosis of cutaneous metastases.

Original languageEnglish
Pages (from-to)901-905
Number of pages5
JournalThyroid
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 1 2008

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Neoplasm Metastasis
Skin
Thyroid Neoplasms
Medullary Thyroid cancer
Human Body
Differential Diagnosis
Phenotype
Biopsy
Recurrence

ASJC Scopus subject areas

  • Endocrinology

Cite this

Santarpia, L., El-Naggar, A. K., Sherman, S. I., Hymes, S. R., Gagel, R. F., Shaw, S., & Sarlis, N. J. (2008). Four patients with cutaneous metastases from medullary thyroid cancer. Thyroid, 18(8), 901-905. https://doi.org/10.1089/thy.2007.0179

Four patients with cutaneous metastases from medullary thyroid cancer. / Santarpia, Libero; El-Naggar, Adel K.; Sherman, Steven I.; Hymes, Sharon R.; Gagel, Robert F.; Shaw, Stephanie; Sarlis, Nicholas J.

In: Thyroid, Vol. 18, No. 8, 01.08.2008, p. 901-905.

Research output: Contribution to journalArticle

Santarpia, L, El-Naggar, AK, Sherman, SI, Hymes, SR, Gagel, RF, Shaw, S & Sarlis, NJ 2008, 'Four patients with cutaneous metastases from medullary thyroid cancer', Thyroid, vol. 18, no. 8, pp. 901-905. https://doi.org/10.1089/thy.2007.0179
Santarpia L, El-Naggar AK, Sherman SI, Hymes SR, Gagel RF, Shaw S et al. Four patients with cutaneous metastases from medullary thyroid cancer. Thyroid. 2008 Aug 1;18(8):901-905. https://doi.org/10.1089/thy.2007.0179
Santarpia, Libero ; El-Naggar, Adel K. ; Sherman, Steven I. ; Hymes, Sharon R. ; Gagel, Robert F. ; Shaw, Stephanie ; Sarlis, Nicholas J. / Four patients with cutaneous metastases from medullary thyroid cancer. In: Thyroid. 2008 ; Vol. 18, No. 8. pp. 901-905.
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