Four-Year Outcome of a Prospective Randomised Trial Comparing Bipolar Plasmakinetic and Monopolar Transurethral Resection of the Prostate

Riccardo Autorino, Rocco Damiano, Giuseppe Di Lorenzo, Giuseppe Quarto, Sisto Perdonà, Massimo D'Armiento, Marco De Sio

Research output: Contribution to journalArticlepeer-review


Background: No data have been published on the midterm efficacy of bipolar transurethral resection of the prostate (TURP). Objective: To evaluate 4-yr results from a prospective randomised trial comparing bipolar TURP with standard monopolar TURP. Design, setting, and participants: Seventy patients with symptomatic benign prostatic hyperplasia were enrolled in this prospective randomised controlled trial in a tertiary-care institution. Inclusion criteria were age >50 yr, good performance status, urinary retention, International Prostate Symptom Score (IPSS) ≥18, and maximal flow rate (Qmax) ≤15 ml/s. Exclusion criteria were prostate volume 3, documented or suspected prostate cancer, neurogenic bladder, bladder stone or diverticula, urethral stricture, and maximal bladder capacity >500 ml. Intervention: Patients underwent standard or bipolar plasmakinetic TURP performed by the same surgeon using the same surgical technique. Measurements: Treatment efficacy was evaluated at 1, 2, 3, and 4 yr by comparing urinary flow rates, IPSS, and estimated postvoid residual (PVR) urine volume. Midterm complications were also recorded. Results and limitations: The number of dropouts was not statistically significantly different in the two groups (p = 0.2). The significant improvements in both groups were maintained at 4 yr for the IPSS, quality of life score, Qmax, and PVR versus baseline values. The main outcome variables at 4 yr for bipolar and monopolar TURP were mean IPSS 6.9 and 6.4 (p = 0.58); mean Qmax 19.8 ml/s and 21.2 ml/s (p = 0.44), and mean PVR volume 42 ml and 45 ml (p = 0.3). Overall, 2 of 32 (6.2%) and 3 of 31 (9.6%) patients required reoperation because of late complications (p = 0.15). The major study limitation was the small sample size. Conclusions: This study represents the secondary, midterm analysis of a previously published trial. Our 4-yr data confirm our initial positive findings for the efficacy and safety of bipolar plasmakinetic TURP. Larger well-designed studies are needed to corroborate these findings.

Original languageEnglish
Pages (from-to)922-931
Number of pages10
JournalEuropean Urology
Issue number4
Publication statusPublished - Apr 2009


  • Benign prostatic hyperplasia
  • Bipolar system
  • Bladder outlet obstruction
  • Midterm outcome
  • Randomised trial
  • Transurethral resection of the prostate

ASJC Scopus subject areas

  • Urology


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