Foxg1 is required for proper separation and formation of sensory cristae during inner ear development

Ho Hwang Chan, Antonio Simeone, Eseng Lai, Doris K. Wu

Research output: Contribution to journalArticlepeer-review

Abstract

The vestibular portion of the inner ear, the three semicircular canals and their sensory cristae, is responsible for detecting angular head movements. It was proposed that sensory cristae induce formation of their non-sensory components, the semicircular canals. Here, we analyzed the inner ears of Foxg1-/- mouse mutants, which display vestibular defects that are in conflict with the above model. In Foxg1-/- ears, the lateral canal is present without the lateral ampulla, which houses the lateral crista. Our gene expression analyses indicate that at the time when canal specification is thought to occur, the prospective lateral crista is present, which could have induced lateral canal formation prior to its demise. Our genetic fate-mapping analyses indicate an improper separation between anterior and lateral cristae in Foxg1-/- mutants. Our data further suggest that a function of Foxg1 in the inner ear is to restrict sensory fate.

Original languageEnglish
Pages (from-to)2725-2734
Number of pages10
JournalDevelopmental Dynamics
Volume238
Issue number11
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Cre
  • Crista
  • Ear
  • Foxg1
  • Mouse
  • Otx1
  • Semicircular
  • Septum cruciatum
  • YFP

ASJC Scopus subject areas

  • Developmental Biology

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