TY - JOUR
T1 - FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis
AU - Sambucci, Manolo
AU - Gargano, Francesca
AU - De Rosa, Veronica
AU - De Bardi, Marco
AU - Picozza, Mario
AU - Placido, Roberta
AU - Ruggieri, Serena
AU - Capone, Alessia
AU - Gasperini, Claudio
AU - Matarese, Giuseppe
AU - Battistini, Luca
AU - Borsellino, Giovanna
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Forkhead box P3 (FoxP3)+ regulatory T cells (Treg) are powerful mediators of immune regulation and immune homeostasis. In humans, Tregs are a heterogeneous population expressing surface markers which define phenotypically and functionally distinct subsets. Moreover, it is now clear that intracellular staining for FoxP3 does not unequivocally identify "true" suppressor cells, since several FoxP3 isoforms exist, and different reagents for FoxP3 detection are available. Here, we propose a strategy to identify potentially functional and suppressive Treg cells in an autoimmune disease like multiple sclerosis, and we suggest that in patients affected by this disease these cells are both reduced in number and functionally exhausted.
AB - Forkhead box P3 (FoxP3)+ regulatory T cells (Treg) are powerful mediators of immune regulation and immune homeostasis. In humans, Tregs are a heterogeneous population expressing surface markers which define phenotypically and functionally distinct subsets. Moreover, it is now clear that intracellular staining for FoxP3 does not unequivocally identify "true" suppressor cells, since several FoxP3 isoforms exist, and different reagents for FoxP3 detection are available. Here, we propose a strategy to identify potentially functional and suppressive Treg cells in an autoimmune disease like multiple sclerosis, and we suggest that in patients affected by this disease these cells are both reduced in number and functionally exhausted.
UR - http://www.scopus.com/inward/record.url?scp=85042797395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042797395&partnerID=8YFLogxK
U2 - 10.1038/s41598-018-21861-5
DO - 10.1038/s41598-018-21861-5
M3 - Article
AN - SCOPUS:85042797395
VL - 8
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 3674
ER -