Analisi frattale della fibrosi epatica

Translated title of the contribution: Fractal analysis of liver fibrosis

Giuseppe Soda, S. Nardoni, D. Bosco, F. Grizzi, N. Dioguardi, Marco Melis

Research output: Contribution to journalArticlepeer-review


This study realized by two different study groups use of Fractal geometry to quantify the complex collagen deposition during chronic liver disease. Thirty standard needle liver biopsy specimens were obtained from patients with chronic HCV-related disease. Three μ-thick sections were cut and stained by means of Picrosirius stain, in order to visualise collagen matrix. The degree of fibrosis was measured using a quantitative scoring system based on the computer-assisted evaluation of the fractal dimension of the deposited collagen surface. The obtained results by both study groups, show that the proposed method is reproducible, rapid and inexpensive. The complex distribution of its collagenous components can be quantified using a single numerical score. This study demonstrated that it is possible to quantify the collagens irregularity in an objective manner and that the study of the fractal properties of the collagen shapes is likely to reveal more about its structure and the complex behaviour of its development.

Translated title of the contributionFractal analysis of liver fibrosis
Original languageItalian
Pages (from-to)98-102
Number of pages5
Issue number2
Publication statusPublished - Apr 2003

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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