Fractal dimension of EEG activity senses neuronal impairment in acute stroke

Filippo Zappasodi, Elzbieta Olejarczyk, Laura Marzetti, Giovanni Assenza, Vittorio Pizzella, Franca Tecchio

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The brain is a self-organizing system which displays self-similarities at different spatial and temporal scales. Thus, the complexity of its dynamics, associated to efficient processing and functional advantages, is expected to be captured by a measure of its scale-free (fractal) properties. Under the hypothesis that the fractal dimension (FD) of the electroencephalographic signal (EEG) is optimally sensitive to the neuronal dysfunction secondary to a brain lesion, we tested the FD's ability in assessing two key processes in acute stroke: the clinical impairment and the recovery prognosis. Resting EEG was collected in 36 patients 4-10 days after a unilateral ischemic stroke in the middle cerebral artery territory and 19 healthy controls. National Health Institute Stroke Scale (NIHss) was collected at T0 and 6 months later. Highuchi FD, its inter-hemispheric asymmetry (FDasy) and spectral band powers were calculated for EEG signals. FD was smaller in patients than in controls (1.447±0.092 vs 1.525±0.105) and its reduction was paired to a worse acute clinical status. FD decrease was associated to alpha increase and beta decrease of oscillatory activity power. Larger FDasy in acute phase was paired to a worse clinical recovery at six months. FD in our patients captured the loss of complexity reflecting the global system dysfunction resulting from the structural damage. This decrease seems to reveal the intimate nature of structure-function unity, where the regional neural multi-scale self-similar activity is impaired by the anatomical lesion. This picture is coherent with neuronal activity complexity decrease paired to a reduced repertoire of functional abilities. FDasy result highlights the functional relevance of the balance between homologous brain structures' activities in stroke recovery.

Original languageEnglish
Article numbere100199
JournalPLoS One
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 26 2014

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Fractals
fractal dimensions
Fractal dimension
stroke
Stroke
Brain
brain
Recovery
lesions (animal)
National Institutes of Health
Middle Cerebral Artery Infarction
arteries
National Institutes of Health (U.S.)
prognosis
Health
Processing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Zappasodi, F., Olejarczyk, E., Marzetti, L., Assenza, G., Pizzella, V., & Tecchio, F. (2014). Fractal dimension of EEG activity senses neuronal impairment in acute stroke. PLoS One, 9(6), [e100199]. https://doi.org/10.1371/journal.pone.0100199

Fractal dimension of EEG activity senses neuronal impairment in acute stroke. / Zappasodi, Filippo; Olejarczyk, Elzbieta; Marzetti, Laura; Assenza, Giovanni; Pizzella, Vittorio; Tecchio, Franca.

In: PLoS One, Vol. 9, No. 6, e100199, 26.06.2014.

Research output: Contribution to journalArticle

Zappasodi, F, Olejarczyk, E, Marzetti, L, Assenza, G, Pizzella, V & Tecchio, F 2014, 'Fractal dimension of EEG activity senses neuronal impairment in acute stroke', PLoS One, vol. 9, no. 6, e100199. https://doi.org/10.1371/journal.pone.0100199
Zappasodi F, Olejarczyk E, Marzetti L, Assenza G, Pizzella V, Tecchio F. Fractal dimension of EEG activity senses neuronal impairment in acute stroke. PLoS One. 2014 Jun 26;9(6). e100199. https://doi.org/10.1371/journal.pone.0100199
Zappasodi, Filippo ; Olejarczyk, Elzbieta ; Marzetti, Laura ; Assenza, Giovanni ; Pizzella, Vittorio ; Tecchio, Franca. / Fractal dimension of EEG activity senses neuronal impairment in acute stroke. In: PLoS One. 2014 ; Vol. 9, No. 6.
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