TY - JOUR
T1 - Fractional CO2 laser for genitourinary syndrome of menopause in breast cancer survivors
T2 - clinical, immunological, and microbiological aspects
AU - Becorpi, Angelamaria
AU - Campisciano, Giuseppina
AU - Zanotta, Nunzia
AU - Tredici, Zelinda
AU - Guaschino, Secondo
AU - Petraglia, Felice
AU - Pieralli, Annalisa
AU - Sisti, Giovanni
AU - De Seta, Francesco
AU - Comar, Manola
PY - 2018/7/1
Y1 - 2018/7/1
N2 - The composition of vaginal microbiome in menopause and cancer survivor women changes dramatically leading to genitourinary syndrome of menopause (GSM) in up to 70% of patients. Recent reports suggest that laser therapy may be valuable as a not hormonal therapeutic modality. The aim of the present study was to evaluate the effects of fractional CO2 laser treatment on the vaginal secretory pathway of a large panel of immune mediators, usually implicated in tissue remodeling and inflammation, and on microbiome composition in postmenopausal breast cancer survivors. The Ion Torrent PGM platform and the Luminex Bio-Plex platform were used for microbiome and immune factor analysis. The significant reduction of clinical symptoms and the non-significant changes in vaginal microbiome support the efficacy and safety of laser treatment. Moreover, the high remodeling status in vaginal epithelium is demonstrated by the significant changes in inflammatory and modulatory cytokine patterns. Laser therapy can be used for the treatment of GSM symptoms and does not show any adverse effects. However, further studies will be needed to clarify its long-term efficacy and other effects.
AB - The composition of vaginal microbiome in menopause and cancer survivor women changes dramatically leading to genitourinary syndrome of menopause (GSM) in up to 70% of patients. Recent reports suggest that laser therapy may be valuable as a not hormonal therapeutic modality. The aim of the present study was to evaluate the effects of fractional CO2 laser treatment on the vaginal secretory pathway of a large panel of immune mediators, usually implicated in tissue remodeling and inflammation, and on microbiome composition in postmenopausal breast cancer survivors. The Ion Torrent PGM platform and the Luminex Bio-Plex platform were used for microbiome and immune factor analysis. The significant reduction of clinical symptoms and the non-significant changes in vaginal microbiome support the efficacy and safety of laser treatment. Moreover, the high remodeling status in vaginal epithelium is demonstrated by the significant changes in inflammatory and modulatory cytokine patterns. Laser therapy can be used for the treatment of GSM symptoms and does not show any adverse effects. However, further studies will be needed to clarify its long-term efficacy and other effects.
KW - Breast cancer
KW - Cytokines/chemokines
KW - Fractional CO laser
KW - Menopause
KW - Microbiome
UR - http://www.scopus.com/inward/record.url?scp=85042616235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042616235&partnerID=8YFLogxK
U2 - 10.1007/s10103-018-2471-3
DO - 10.1007/s10103-018-2471-3
M3 - Article
C2 - 29492713
AN - SCOPUS:85042616235
VL - 33
SP - 1047
EP - 1054
JO - Lasers in Medical Science
JF - Lasers in Medical Science
SN - 0268-8921
IS - 5
ER -