Abstract
Working with the antimetabolic chemopredictivity assay on short term cultures we evidenced a correlation between in vitro chemosensitivity of colorectal cancer and fractional incorporation of radionucleotides. Four difTerent drugs (5-FU. mitomycin C, 4¢-iododeoxydoxorubicin and ruboxyl, a nitroxyl derivative of daunorubicin) were tested on 102 tumor cultures. The extent of3H-TdR and3H-UdR incorporation into DN A and RNA in the related control cultures was in relationship with the chemosensitivity of the tumor. Along with the labeling index this simple metabolic-kinetic trait may gain a role for the screening of tumor phenotypes sensitive to chemotherapy.
Original language | English |
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Pages (from-to) | 510-516 |
Number of pages | 7 |
Journal | Oncology |
Volume | 48 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1991 |
Keywords
- 5-Fluorouracil
- Cell kinetics
- Chemosensitivity assays
- Colorectal cancer
- Mitomycin C
- Tumor chemotherapy
ASJC Scopus subject areas
- Cancer Research
- Oncology