Chronic intrahepatic cholestasis is characterized by reduced biliary secretion of bile acids. A reduced ileal load with bile acids causes upregulation of ileal absorption efficiency in rodents, yet no data are available for humans. The aim of the study was to assess whether this mechanism occurs in patients with cholestasis leading to a decrease in the fractional turnover rate of bile acids. Fractional turnover rate of bile acids was measured according to the half-life of the orally administered γ-emitting bile acid analogue 75Selena-homocholic acid taurine (75SeHCAT) in 12 patients with primary biliary cirrhosis, and compared with the results of 15 healthy control subjects. The 75SeHCAT half-life in patients with primary biliary cirrhosis was similar to healthy controls (2.51 ± 0.5 vs. 2.96 ± 0.81 days). No correlation was found between serum levels of bile acids and 75SeHCAT half-life in patients with primary biliary cirrhosis. Primary biliary cirrhosis in an early stage of disease does not cause a decrease in the fractional turnover rate of bile acids. This does not lend support to the hypothesis of upregulation of the bile acid ileal absorption efficiency during chronic cholestasis.
|Number of pages||4|
|Publication status||Published - 1996|
- Selena-homocholic acid taurine
- Bile acid kinetic
- Primary biliary cirrhosis
ASJC Scopus subject areas