Fragile-X syndrome: A particular epileptogenic EEG pattern

S. A. Musumeci; R. M. Colognola; R. Ferri; G. L. Gigli; M. A. Petrella; S. Sanfilippo; P. Bergonzi; C. A. Tassinari

Fragile-X syndrome: A particular epileptogenic EEG pattern

S. A. Musumeci, R. M. Colognola, R. Ferri, G. L. Gigli, M. A. Petrella, S. Sanfilippo, P. Bergonzi, C. A. Tassinari

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Abstract

A clinical and EEG study of 12 fragile-X syndrome subjects (six with epilepsy) is presented. All subjects had clinical-family history examinations, EEG evaluations, and karyotyping. Spikes were present in the sleep EEG of one nonepileptic and four epileptic subjects; these spikes were similar in location, occurrence, voltage, frequency, and morphology (and similar to those of the Rolandic spikes). These data, together with the clinical similarities (type of epilepsy, responses to drugs, ages of seizure onset, etc.), have resulted in the postulation of EEG characteristics of epileptic and nonepileptic fragile-X patients. However, further studies with fragile-X patients are needed to confirm this hypothesis.

Original language	English
Pages (from-to)	41-47
Number of pages	7
Journal	Epilepsia
Volume	29
Issue number	1
Publication status	Published - 1988

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

Cite this

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title = "Fragile-X syndrome: A particular epileptogenic EEG pattern",

abstract = "A clinical and EEG study of 12 fragile-X syndrome subjects (six with epilepsy) is presented. All subjects had clinical-family history examinations, EEG evaluations, and karyotyping. Spikes were present in the sleep EEG of one nonepileptic and four epileptic subjects; these spikes were similar in location, occurrence, voltage, frequency, and morphology (and similar to those of the Rolandic spikes). These data, together with the clinical similarities (type of epilepsy, responses to drugs, ages of seizure onset, etc.), have resulted in the postulation of EEG characteristics of epileptic and nonepileptic fragile-X patients. However, further studies with fragile-X patients are needed to confirm this hypothesis.",

author = "Musumeci, {S. A.} and Colognola, {R. M.} and R. Ferri and Gigli, {G. L.} and Petrella, {M. A.} and S. Sanfilippo and P. Bergonzi and Tassinari, {C. A.}",

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AU - Musumeci, S. A.

AU - Colognola, R. M.

AU - Ferri, R.

AU - Gigli, G. L.

AU - Petrella, M. A.

AU - Sanfilippo, S.

AU - Bergonzi, P.

AU - Tassinari, C. A.

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N2 - A clinical and EEG study of 12 fragile-X syndrome subjects (six with epilepsy) is presented. All subjects had clinical-family history examinations, EEG evaluations, and karyotyping. Spikes were present in the sleep EEG of one nonepileptic and four epileptic subjects; these spikes were similar in location, occurrence, voltage, frequency, and morphology (and similar to those of the Rolandic spikes). These data, together with the clinical similarities (type of epilepsy, responses to drugs, ages of seizure onset, etc.), have resulted in the postulation of EEG characteristics of epileptic and nonepileptic fragile-X patients. However, further studies with fragile-X patients are needed to confirm this hypothesis.

AB - A clinical and EEG study of 12 fragile-X syndrome subjects (six with epilepsy) is presented. All subjects had clinical-family history examinations, EEG evaluations, and karyotyping. Spikes were present in the sleep EEG of one nonepileptic and four epileptic subjects; these spikes were similar in location, occurrence, voltage, frequency, and morphology (and similar to those of the Rolandic spikes). These data, together with the clinical similarities (type of epilepsy, responses to drugs, ages of seizure onset, etc.), have resulted in the postulation of EEG characteristics of epileptic and nonepileptic fragile-X patients. However, further studies with fragile-X patients are needed to confirm this hypothesis.

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Fragile-X syndrome: A particular epileptogenic EEG pattern

Abstract

ASJC Scopus subject areas

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