Frailty assessment in elective gastrointestinal oncogeriatric surgery: Predictors of one-year mortality and functional status

Chiara Giannotti, Silvia Sambuceti, Alessio Signori, Alberto Ballestrero, Roberto Murialdo, Emanuele Romairone, Stefano Scabini, Irene Caffa, Patrizio Odetti, Alessio Nencioni, Fiammetta Monacelli

Research output: Contribution to journalArticlepeer-review


Objectives: Perioperative frailty assessment is still a challenge, especially in oncogeriatrics. We aimed at assessing the diagnostic accuracy of the 40 items Frailty Index (FI) as compared to the comprehensive geriatric assessment (CGA) for the prediction of one-year mortality and functional status after colorectal surgery in old-age subjects. Material and methods: Ninety-nine consecutive patients aged 65 years or older who were candidate for elective gastrointestinal cancer surgery, with G8 score ≤ 14 were enrolled and subjected to CGA and to frailty stratification according to the 40-items FI. Long-term outcomes including one-year mortality and functional decline were collected. Results: Mean patient age was 80.3 ± 5.6 years. Colorectal cancer was the most common diagnosis. The most prevalent clinical phenotype was pre-frail. CGA and FI showed similar predictive accuracy in identifying one-year mortality after surgery and patient functional status. Our multivariate analysis indicated the pre-morbid functional status (IADL) and cancer stage as the most significant predictors of one-year mortality. Conclusions: This is the first study to investigate the prognostic accuracy of the 40-items FI as compared to CGA in a vulnerable octogenarian cancer population. Its results are consistent with patient functional status being a mediator of frailty and with both serving as intertwined markers of clinical vulnerability. In addition, according to our results, cancer and specific environmental stressors, such as surgery, are likely to affect the frailty trajectory.

Original languageEnglish
Pages (from-to)716-723
Number of pages8
JournalJournal of Geriatric Oncology
Issue number5
Publication statusPublished - Sep 2019


  • Cancer
  • Frailty assessment
  • Long-term mortality and functional decline
  • Older adults
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Geriatrics and Gerontology


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