Abstract
Frailty in the elderly is a state of vulnerability to poor resolution of homoeostasis after a stressor event and is a consequence of cumulative decline in many physiological systems during a lifetime. This cumulative decline depletes homoeostatic reserves until minor stressor events trigger disproportionate changes in health status. It is usually associated to adverse health outcomes and to one-year mortality risk. Physical exercise has found to be effective in preventing frailty and disability in this population. Chronic kidney disease (CKD) is also a clinical condition where protein energy-wasting, sarcopenia and dynapenia ,very common symptoms in the frail elderly, may occur. Moreover elderly and CKD patients are both affected by an impaired physical performance that may be reversed by physical exercise with an improvement of the survival rate. These similarities suggest that frailty may be a common pathway of aging and CKD that may induce disability and that can be prevented by a multidimensional approach in which physical exercise plays an important role.
| Original language | English |
|---|---|
| Pages (from-to) | 164-168 |
| Number of pages | 5 |
| Journal | Kidney and Blood Pressure Research |
| Volume | 39 |
| DOIs | |
| Publication status | Published - Apr 18 2014 |
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Keywords
- Aging
- Chronic kidney disease
- Disability
- Frailty
- Physical exercise
ASJC Scopus subject areas
- Nephrology
- Cardiology and Cardiovascular Medicine
- Medicine(all)
Cite this
Frailty, disability and physical exercise in the aging process and in chronic kidney disease. / Greco, Antonio; Paroni, Giulia; Seripa, Davide; Addante, Filomena; Dagostino, Mariangela P.; Aucella, Filippo.
In: Kidney and Blood Pressure Research, Vol. 39, 18.04.2014, p. 164-168.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frailty, disability and physical exercise in the aging process and in chronic kidney disease
AU - Greco, Antonio
AU - Paroni, Giulia
AU - Seripa, Davide
AU - Addante, Filomena
AU - Dagostino, Mariangela P.
AU - Aucella, Filippo
PY - 2014/4/18
Y1 - 2014/4/18
N2 - Frailty in the elderly is a state of vulnerability to poor resolution of homoeostasis after a stressor event and is a consequence of cumulative decline in many physiological systems during a lifetime. This cumulative decline depletes homoeostatic reserves until minor stressor events trigger disproportionate changes in health status. It is usually associated to adverse health outcomes and to one-year mortality risk. Physical exercise has found to be effective in preventing frailty and disability in this population. Chronic kidney disease (CKD) is also a clinical condition where protein energy-wasting, sarcopenia and dynapenia ,very common symptoms in the frail elderly, may occur. Moreover elderly and CKD patients are both affected by an impaired physical performance that may be reversed by physical exercise with an improvement of the survival rate. These similarities suggest that frailty may be a common pathway of aging and CKD that may induce disability and that can be prevented by a multidimensional approach in which physical exercise plays an important role.
AB - Frailty in the elderly is a state of vulnerability to poor resolution of homoeostasis after a stressor event and is a consequence of cumulative decline in many physiological systems during a lifetime. This cumulative decline depletes homoeostatic reserves until minor stressor events trigger disproportionate changes in health status. It is usually associated to adverse health outcomes and to one-year mortality risk. Physical exercise has found to be effective in preventing frailty and disability in this population. Chronic kidney disease (CKD) is also a clinical condition where protein energy-wasting, sarcopenia and dynapenia ,very common symptoms in the frail elderly, may occur. Moreover elderly and CKD patients are both affected by an impaired physical performance that may be reversed by physical exercise with an improvement of the survival rate. These similarities suggest that frailty may be a common pathway of aging and CKD that may induce disability and that can be prevented by a multidimensional approach in which physical exercise plays an important role.
KW - Aging
KW - Chronic kidney disease
KW - Disability
KW - Frailty
KW - Physical exercise
UR - http://www.scopus.com/inward/record.url?scp=84906008765&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906008765&partnerID=8YFLogxK
U2 - 10.1159/000355792
DO - 10.1159/000355792
M3 - Article
C2 - 25117919
AN - SCOPUS:84906008765
VL - 39
SP - 164
EP - 168
JO - Kidney and Blood Pressure Research
JF - Kidney and Blood Pressure Research
SN - 1420-4096
ER -