Abstract
Background: Frailty is a clinical syndrome generally associated with a greater risk for adverse outcomes such as falls, disability, institutionalization, and death. Cognition and dementia have already been considered as components of frailty, but the role of frailty as a possible determinant of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) has been poorly investigated. We estimated the predictive role of frailty syndrome on incident dementia and its subtypes in a nondemented, Italian, older population. Methods: We evaluated 2581 individuals recruited from the Italian Longitudinal Study on Aging sample population consisting of 5632 subjects aged 65 to 84 years and with a 3.9-year median follow-up. A phenotype of frailty according to a modified measurement of Cardiovascular Health Study criteria was operationalized. Dementia, AD, and VaD were classified using current published criteria. Results: Over a 3.5-year follow-up, 65 of 2581 (2.5%) older subjects, 16 among 252 frail individuals (6.3%), of which 9 were affected by VaD (3.6%), developed overall dementia. In a proportional hazards model, frailty syndrome was associated with a significantly increased risk of overall dementia (adjusted hazard ratio: 1.85; 95% confidence interval: 1.01-3.40) and, in particular, VaD (adjusted hazard ratio: 2.68; 95% confidence interval: 1.16-7.17). The risk of AD or other types of dementia did not significantly change in frail individuals in comparison with subjects without frailty syndrome. Conclusion: In our large population-based sample, frailty syndrome was a short-term predictor of overall dementia and VaD.
| Original language | English |
|---|---|
| Pages (from-to) | 113-122 |
| Number of pages | 10 |
| Journal | Alzheimer's and Dementia |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 2013 |
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Keywords
- Alzheimer's disease
- Cerebrovascular disease
- Cognition
- Dementia
- Frailty
- Vascular dementia
ASJC Scopus subject areas
- Health Policy
- Epidemiology
- Geriatrics and Gerontology
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
- Developmental Neuroscience
- Clinical Neurology
Cite this
Frailty syndrome and the risk of vascular dementia : The Italian Longitudinal Study on Aging. / Solfrizzi, Vincenzo; Scafato, Emanuele; Frisardi, Vincenza; Seripa, Davide; Logroscino, Giancarlo; Maggi, Stefania; Imbimbo, Bruno P.; Galluzzo, Lucia; Baldereschi, Marzia; Gandin, Claudia; Di Carlo, Antonio; Inzitari, Domenico; Crepaldi, Gaetano; Pilotto, Alberto; Panza, Francesco.
In: Alzheimer's and Dementia, Vol. 9, No. 2, 03.2013, p. 113-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frailty syndrome and the risk of vascular dementia
T2 - The Italian Longitudinal Study on Aging
AU - Solfrizzi, Vincenzo
AU - Scafato, Emanuele
AU - Frisardi, Vincenza
AU - Seripa, Davide
AU - Logroscino, Giancarlo
AU - Maggi, Stefania
AU - Imbimbo, Bruno P.
AU - Galluzzo, Lucia
AU - Baldereschi, Marzia
AU - Gandin, Claudia
AU - Di Carlo, Antonio
AU - Inzitari, Domenico
AU - Crepaldi, Gaetano
AU - Pilotto, Alberto
AU - Panza, Francesco
PY - 2013/3
Y1 - 2013/3
N2 - Background: Frailty is a clinical syndrome generally associated with a greater risk for adverse outcomes such as falls, disability, institutionalization, and death. Cognition and dementia have already been considered as components of frailty, but the role of frailty as a possible determinant of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) has been poorly investigated. We estimated the predictive role of frailty syndrome on incident dementia and its subtypes in a nondemented, Italian, older population. Methods: We evaluated 2581 individuals recruited from the Italian Longitudinal Study on Aging sample population consisting of 5632 subjects aged 65 to 84 years and with a 3.9-year median follow-up. A phenotype of frailty according to a modified measurement of Cardiovascular Health Study criteria was operationalized. Dementia, AD, and VaD were classified using current published criteria. Results: Over a 3.5-year follow-up, 65 of 2581 (2.5%) older subjects, 16 among 252 frail individuals (6.3%), of which 9 were affected by VaD (3.6%), developed overall dementia. In a proportional hazards model, frailty syndrome was associated with a significantly increased risk of overall dementia (adjusted hazard ratio: 1.85; 95% confidence interval: 1.01-3.40) and, in particular, VaD (adjusted hazard ratio: 2.68; 95% confidence interval: 1.16-7.17). The risk of AD or other types of dementia did not significantly change in frail individuals in comparison with subjects without frailty syndrome. Conclusion: In our large population-based sample, frailty syndrome was a short-term predictor of overall dementia and VaD.
AB - Background: Frailty is a clinical syndrome generally associated with a greater risk for adverse outcomes such as falls, disability, institutionalization, and death. Cognition and dementia have already been considered as components of frailty, but the role of frailty as a possible determinant of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) has been poorly investigated. We estimated the predictive role of frailty syndrome on incident dementia and its subtypes in a nondemented, Italian, older population. Methods: We evaluated 2581 individuals recruited from the Italian Longitudinal Study on Aging sample population consisting of 5632 subjects aged 65 to 84 years and with a 3.9-year median follow-up. A phenotype of frailty according to a modified measurement of Cardiovascular Health Study criteria was operationalized. Dementia, AD, and VaD were classified using current published criteria. Results: Over a 3.5-year follow-up, 65 of 2581 (2.5%) older subjects, 16 among 252 frail individuals (6.3%), of which 9 were affected by VaD (3.6%), developed overall dementia. In a proportional hazards model, frailty syndrome was associated with a significantly increased risk of overall dementia (adjusted hazard ratio: 1.85; 95% confidence interval: 1.01-3.40) and, in particular, VaD (adjusted hazard ratio: 2.68; 95% confidence interval: 1.16-7.17). The risk of AD or other types of dementia did not significantly change in frail individuals in comparison with subjects without frailty syndrome. Conclusion: In our large population-based sample, frailty syndrome was a short-term predictor of overall dementia and VaD.
KW - Alzheimer's disease
KW - Cerebrovascular disease
KW - Cognition
KW - Dementia
KW - Frailty
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=84875370266&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875370266&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2011.09.223
DO - 10.1016/j.jalz.2011.09.223
M3 - Article
C2 - 23245560
AN - SCOPUS:84875370266
VL - 9
SP - 113
EP - 122
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
IS - 2
ER -