Free and bound leptin in prepubertal children with Down's syndrome and different degrees of adiposity

Paolo Magni, M. Ruscica, E. Dozio, E. Roti, F. Licastro, M. Motta, M. M. Corsi

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate plasma total, free (FL) and protein-bound (BL) leptin in children with Down's syndrome (DS) and different degrees of adiposity and its relationship with thyroid stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3). Subjects: A total of 24 prepubertal clinically euthyroid DS children. Methods: Plasma leptin, TSH, FT4, and FT3 concentrations were determined by immunometric /radioimmunologic assays. FL and BL were evaluated by fast protein liquid chromatography. Results: In DS children, leptin circulates in two fractions corresponding to BL and FL. The amount of BL and FL is negatively and positively correlated to body mass index (BMI), respectively. Plasma leptin concentrations correlate with BMI, but not with TSH, FT4, and FT3. Conclusions: In prepubertal DS children, leptin circulates as both BL and FL, correlates with adiposity and its concentration appears independent of thyroid function.

Original languageEnglish
Pages (from-to)1547-1549
Number of pages3
JournalEuropean Journal of Clinical Nutrition
Volume58
Issue number11
DOIs
Publication statusPublished - Nov 2004

Keywords

  • Bound leptin
  • Down's syndrome
  • Free leptin
  • Prepubertal children
  • Thyroid function

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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