Free erythrocyte protoporphyrin as an indicator of the biological effect of lead in adult males - III. Behavior of free erythrocyte protoporphyrin in workers with past lead exposure

L. Alessio, P. A. Bertazzi, O. Monelli, F. Toffoletto

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between FEP and the indicators of dose (PbB, PbU, PbU-EDTA) was examined in a group of male subjects who had left lead-exposing jobs more than 12 months previously. In these subjects, FEP and PbB and FEP and PbU were correlated to a distinctly lower degree compared to previous findings in currently exposed subjects, although the correlations were still statistically significant. In the previously exposed subjects the erythrocyte metabolite displayed definitely higher values than those found in currently exposed subjects at the same PbB or PbU levels. A very close correlation was found between FEP and PbU-EDTA, as was found in exposed subjects. The regression curve assumed an identical profile in the two situations. From these results it may be concluded that FEP persists at high levels for a long time after cessation of exposure due to a direct inhibition of heme synthetase caused by lead released from the tissue deposits. It should be noted that FEP proved to be a valid test for predicting the amount of lead storage, even a long time after cessation of exposure.

Original languageEnglish
Pages (from-to)77-86
Number of pages10
JournalInternational Archives of Occupational and Environmental Health
Volume38
Issue number2
DOIs
Publication statusPublished - Jun 1976

Keywords

  • Chelatable lead
  • Correlation
  • Current and past exposure
  • Lead
  • Lead in urine
  • Non-linear regresssion
  • Protoporphyrin in erythrocytes Lead in blood
  • Validity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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