Free light chains of immunoglobulins in the cerebrospinal fluid of human immunodeficiency virus type 1-infected patients

Paolo Gallo; Maria Grazia Piccinno; Anita De Rossi; Silvana Pagni; Alberto Amadori; Luigi Chieco-Bianchi; Bruno Tavolato

doi:10.1016/0165-5728(90)90005-8

Free light chains of immunoglobulins in the cerebrospinal fluid of human immunodeficiency virus type 1-infected patients

Paolo Gallo, Maria Grazia Piccinno, Anita De Rossi, Silvana Pagni, Alberto Amadori, Luigi Chieco-Bianchi, Bruno Tavolato

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterized by restricted heterogeneity with regard to both isoelectric point and the molecular weight, and were mainly composed by dimers rather than monomers. A striking prevalence of lambda FLC was also observed. Local production of FLC can be taken as a marker of an ongoing immunopathological process within the central nervous system (CNS) in HIV-1-infected patients. A deregulation of Ig production by intrathecally activated B cells may be hypothesized.

Original language	English
Pages (from-to)	229-238
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/0165-5728(90)90005-8
Publication status	Published - 1990

Keywords

B cell
Cerebrospinal fluid
Free light chain
Human immunodeficiency virus type 1

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Clinical Neurology
Neurology

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Free light chains of immunoglobulins in the cerebrospinal fluid of human immunodeficiency virus type 1-infected patients. / Gallo, Paolo; Piccinno, Maria Grazia; De Rossi, Anita; Pagni, Silvana; Amadori, Alberto; Chieco-Bianchi, Luigi; Tavolato, Bruno.

In: Journal of Neuroimmunology, Vol. 26, No. 3, 1990, p. 229-238.

Research output: Contribution to journal › Article › peer-review

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AU - Amadori, Alberto

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AU - Tavolato, Bruno

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