TY - JOUR
T1 - Free light chains of immunoglobulins in the cerebrospinal fluid of human immunodeficiency virus type 1-infected patients
AU - Gallo, Paolo
AU - Piccinno, Maria Grazia
AU - De Rossi, Anita
AU - Pagni, Silvana
AU - Amadori, Alberto
AU - Chieco-Bianchi, Luigi
AU - Tavolato, Bruno
PY - 1990
Y1 - 1990
N2 - The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterized by restricted heterogeneity with regard to both isoelectric point and the molecular weight, and were mainly composed by dimers rather than monomers. A striking prevalence of lambda FLC was also observed. Local production of FLC can be taken as a marker of an ongoing immunopathological process within the central nervous system (CNS) in HIV-1-infected patients. A deregulation of Ig production by intrathecally activated B cells may be hypothesized.
AB - The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterized by restricted heterogeneity with regard to both isoelectric point and the molecular weight, and were mainly composed by dimers rather than monomers. A striking prevalence of lambda FLC was also observed. Local production of FLC can be taken as a marker of an ongoing immunopathological process within the central nervous system (CNS) in HIV-1-infected patients. A deregulation of Ig production by intrathecally activated B cells may be hypothesized.
KW - B cell
KW - Cerebrospinal fluid
KW - Free light chain
KW - Human immunodeficiency virus type 1
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U2 - 10.1016/0165-5728(90)90005-8
DO - 10.1016/0165-5728(90)90005-8
M3 - Article
C2 - 2106530
AN - SCOPUS:0025019696
VL - 26
SP - 229
EP - 238
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 3
ER -