Free-malondialdehyde (F-MDA)

A plasmatic marker of clinical instability in coronary artery disease

A. Loaldi, V. Cavalca, D. Zavalloni, G. Cighetti, F. Bamonti, A. Bartorelli, P. Montorsi, F. Fabbiocchi, M. D. Guazzi

Research output: Contribution to journalArticle

Abstract

Background: Macrophage derived proteolytic enzymes induce collagen catabolism, resulting in a weakened fibrous cap of coronary atherosclerotic plaques. The subsequent ulceration and endoluminal thrombosis may lead to unstable angina and myocardial infarction. Futhermore, macrophage activation is followed by the release of oxigen free radicals whose activity may be monitored by plasmatic concentration of free-malondialdehyde (F-MDA). Elevated F-MDA values are considered suggestive of a rising rate of macrophage-mediated lipid peroxidation. v Aim: To evaluate F-MDA as a marker of macrophage activation and, then, of plaque and clinical instability. Methods: We enrolled 15 pts with stable angina (SA), 22 with unstable angina (UA) and 12 with myocardial infarction (AMI). Patients were well-matched for age, sex and coronary risk factors. F-MDA was assessed by gas chromatography-mass spectrometry Data were analysed using Wilcoxon test and χ2 test. Results: F-MDA was significantly higher in patients with UA and AMI when compared with SA group (0.58μM and 0.65μM vs 0.31μM, as median values p

Original languageEnglish
JournalHeart
Volume83
Issue numberSUPPL. 2
Publication statusPublished - Jun 2000

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Malondialdehyde
Coronary Artery Disease
Biomarkers
Unstable Angina
Stable Angina
Macrophage Activation
Myocardial Infarction
Macrophages
Atherosclerotic Plaques
Gas Chromatography-Mass Spectrometry
Lipid Peroxidation
Free Radicals
Thrombosis
Peptide Hydrolases
Collagen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Free-malondialdehyde (F-MDA) : A plasmatic marker of clinical instability in coronary artery disease. / Loaldi, A.; Cavalca, V.; Zavalloni, D.; Cighetti, G.; Bamonti, F.; Bartorelli, A.; Montorsi, P.; Fabbiocchi, F.; Guazzi, M. D.

In: Heart, Vol. 83, No. SUPPL. 2, 06.2000.

Research output: Contribution to journalArticle

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T2 - A plasmatic marker of clinical instability in coronary artery disease

AU - Loaldi, A.

AU - Cavalca, V.

AU - Zavalloni, D.

AU - Cighetti, G.

AU - Bamonti, F.

AU - Bartorelli, A.

AU - Montorsi, P.

AU - Fabbiocchi, F.

AU - Guazzi, M. D.

PY - 2000/6

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N2 - Background: Macrophage derived proteolytic enzymes induce collagen catabolism, resulting in a weakened fibrous cap of coronary atherosclerotic plaques. The subsequent ulceration and endoluminal thrombosis may lead to unstable angina and myocardial infarction. Futhermore, macrophage activation is followed by the release of oxigen free radicals whose activity may be monitored by plasmatic concentration of free-malondialdehyde (F-MDA). Elevated F-MDA values are considered suggestive of a rising rate of macrophage-mediated lipid peroxidation. v Aim: To evaluate F-MDA as a marker of macrophage activation and, then, of plaque and clinical instability. Methods: We enrolled 15 pts with stable angina (SA), 22 with unstable angina (UA) and 12 with myocardial infarction (AMI). Patients were well-matched for age, sex and coronary risk factors. F-MDA was assessed by gas chromatography-mass spectrometry Data were analysed using Wilcoxon test and χ2 test. Results: F-MDA was significantly higher in patients with UA and AMI when compared with SA group (0.58μM and 0.65μM vs 0.31μM, as median values p

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