Free protein S deficiency is a risk factor for venous thrombosis

Elena M. Faioni, Carla Valsecchi, Alessandra Palla, Emanuela Taioli, Cristina Razzari, Pier Mannuccio Mannucci

Research output: Contribution to journalArticle

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Abstract

A recent study suggests that protein S deficiency is not a risk factor for venous thrombosis. Since this unexpected finding would have important clinical implications if confirmed, we performed a case-control study with the aim to determine the prevalence of protein S deficiency in patients with thrombosis and in healthy individuals taken from the general population and the relative risk of thrombosis in protein S-deficient patients. Free protein S concentration was measured in 327 consecutive patients with at least one venous thrombotic episode and in 317 age- and sex-matched control individuals. Different normal reference ranges were obtained and adopted for men and women. Protein S deficiency was found in 3.1% (95% CI: 1.5-5.2) of patients and in 1.3% of controls (95% CI: 0.3-2.8). Ten patients and 4 control subjects had protein S deficiency, which determined a relative risk of thrombosis (sex- and age-adjusted odds ratio) of 2.4 (95% CI: 0.8-7.9). When men and women were analyzed separately, the risk was 5.0 (95% CI: 0.6-43.6) and 1.6 (95% CI: 0.4-6.7) respectively. PS-deficient men had more thrombotic episodes than women and later in life. Multivariate analysis established that sex was an independent determinant of the number of episodes, as was age, while PS deficiency was not. However sex and PS deficiency status were both determinants of age at first thrombotic episode.

Original languageEnglish
Pages (from-to)1343-1346
Number of pages4
JournalThrombosis and Haemostasis
Volume78
Issue number5
Publication statusPublished - Nov 1997

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Protein S Deficiency
Venous Thrombosis
Thrombosis
Protein S
Reference Values
Case-Control Studies
Multivariate Analysis
Odds Ratio
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Faioni, E. M., Valsecchi, C., Palla, A., Taioli, E., Razzari, C., & Mannucci, P. M. (1997). Free protein S deficiency is a risk factor for venous thrombosis. Thrombosis and Haemostasis, 78(5), 1343-1346.

Free protein S deficiency is a risk factor for venous thrombosis. / Faioni, Elena M.; Valsecchi, Carla; Palla, Alessandra; Taioli, Emanuela; Razzari, Cristina; Mannucci, Pier Mannuccio.

In: Thrombosis and Haemostasis, Vol. 78, No. 5, 11.1997, p. 1343-1346.

Research output: Contribution to journalArticle

Faioni, EM, Valsecchi, C, Palla, A, Taioli, E, Razzari, C & Mannucci, PM 1997, 'Free protein S deficiency is a risk factor for venous thrombosis', Thrombosis and Haemostasis, vol. 78, no. 5, pp. 1343-1346.
Faioni EM, Valsecchi C, Palla A, Taioli E, Razzari C, Mannucci PM. Free protein S deficiency is a risk factor for venous thrombosis. Thrombosis and Haemostasis. 1997 Nov;78(5):1343-1346.
Faioni, Elena M. ; Valsecchi, Carla ; Palla, Alessandra ; Taioli, Emanuela ; Razzari, Cristina ; Mannucci, Pier Mannuccio. / Free protein S deficiency is a risk factor for venous thrombosis. In: Thrombosis and Haemostasis. 1997 ; Vol. 78, No. 5. pp. 1343-1346.
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