Free radicals and endothelial dysfunction: Potential positive effects of TNF-α inhibitors

Giuseppe Murdaca, Francesca Spanò, Paola Cagnati, Francesco Puppo

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: During the last decade many new biological immune modulators have entered the market as new therapeutic principles. Tumor necrosis factor (TNF)-α is a pro-inflammatory cytokine known to a have a key role in the pathogenic mechanisms of various immune-mediated or inflammatory diseases. However, TNF- α also plays a key role in endothelial dysfunction and, thus, in the development and progression of atherosclerosis. What, then, is the potential therapeutic role of TNF-α inhibitors? Methods: We analysed the current literature concerning the administration of TNF-α inhibitors and their potential benefits upon endothelial function. Results: TNF-α inhibitors decrease the serum levels of inflammatory markers such as TNF-α itself, CRP, IL-6, and increased the tissue expression of endothelial NO synthase and the vasodilatory response to bradykinin. Discussion: TNF-α inhibitors may change the progression of endothelial dysfunction and, thus, slow down the atherosclerotic process.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalRedox Report
Volume18
Issue number3
DOIs
Publication statusPublished - May 2013

Keywords

  • Atherosclerosis
  • Endothelial dysfunction
  • Free radicals
  • TNF-α inhibitors
  • VEGF

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Physiology

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