Frequencies of specific peptides in intrinsic disordered protein domains

Susan Costantini, Maria Costantini, Giovanni Colonna

Research output: Contribution to journalArticle


We evaluated the i-peptides occurrence frequency in the protein sequences, belonging to two reference datasets containing structured and disordered protein domains. Moreover we estimated the most frequent i-peptides (with i= 2, 3, 4) into these sequences in order to select specific i-peptides for each structural classification. According to these specific i-peptides, a new binary classification method was developed for predicting if a given protein sequence can be classified as "disordered" or "structured". The best results were obtained using the tri-peptides, much more able to gain structural information from sequences compared to the di-peptides.

Original languageEnglish
Pages (from-to)1398-1402
Number of pages5
JournalProtein and Peptide Letters
Issue number11
Publication statusPublished - Nov 2010


  • Binary classification method
  • Disorder prediction
  • Disordered proteins
  • Peptides occurrence frequency
  • Protein folding
  • Protein unfolding

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology

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    Costantini, S., Costantini, M., & Colonna, G. (2010). Frequencies of specific peptides in intrinsic disordered protein domains. Protein and Peptide Letters, 17(11), 1398-1402.