TY - JOUR
T1 - Frequenza e associazioni cliniche degli anticorpi anti citoplasma dei neutrofili. Un'esperienza locale
AU - Defendenti, Caterina
AU - Spina, Maria Francesca
AU - Grosso, Silvia
AU - Longo, Margherita
AU - Bollani, Simona
AU - Cereda, Aldo
AU - Saibeni, Simone
AU - Guercilena, Giacinto
AU - Atzeni, Fabiola
AU - Sarzi-Puttini, Piercarlo
PY - 2010
Y1 - 2010
N2 - Serologic and clinical aspects of 50 positives patients for antineutrophil cytoplasmic antibodies (ANCA) have been evaluated (age range 7-94 years, mean age 43 years). 40 (80%) were females. Antineutrophil nuclear antibodies (pANNA), in which the antigenic specificity is unknown, were detected in seventeen patients (34%). About half of these cases (8 patients) had primary sclerosing cholangitis and other 7 patients had severe ulcerative colitis. Two pANNA patients, with increased susceptibility to infections, had undefined diagnosis. Both had thalassemic trait. Anti MPO were detected in 9 patients in which segmental lesions prevail and anti-PR3 were detected in 9 patients with granulomatous component. The patients with higher levels of these autoantibodies (40%) had the typical syndromes described in literature (vasculitis ANCA-related) although patients with lower autoantibodies levels (60%) mostly present variable clinical symptoms with unspecified diagnosis. Fourteen patients were positive for atypical ANCA detectable with commercial kits. They present variable clinical symptoms with unspecified diagnosis but show granulomatous or neoplastic lungs and bowel involvement. Both have mostly contact with environmental microorganisms. All cases are characterized by chronic inflammatory lesions in which the relapses correle with infectious disorder.
AB - Serologic and clinical aspects of 50 positives patients for antineutrophil cytoplasmic antibodies (ANCA) have been evaluated (age range 7-94 years, mean age 43 years). 40 (80%) were females. Antineutrophil nuclear antibodies (pANNA), in which the antigenic specificity is unknown, were detected in seventeen patients (34%). About half of these cases (8 patients) had primary sclerosing cholangitis and other 7 patients had severe ulcerative colitis. Two pANNA patients, with increased susceptibility to infections, had undefined diagnosis. Both had thalassemic trait. Anti MPO were detected in 9 patients in which segmental lesions prevail and anti-PR3 were detected in 9 patients with granulomatous component. The patients with higher levels of these autoantibodies (40%) had the typical syndromes described in literature (vasculitis ANCA-related) although patients with lower autoantibodies levels (60%) mostly present variable clinical symptoms with unspecified diagnosis. Fourteen patients were positive for atypical ANCA detectable with commercial kits. They present variable clinical symptoms with unspecified diagnosis but show granulomatous or neoplastic lungs and bowel involvement. Both have mostly contact with environmental microorganisms. All cases are characterized by chronic inflammatory lesions in which the relapses correle with infectious disorder.
KW - Antineutrophil cytoplasmic antibodies
KW - Antineutrophil nuclear antibodies
KW - BPI autoantibodies
KW - Inflammatory bowel disease
KW - Polyarteritis nodosa
KW - PR3 autoantibodies
KW - Systemic vasculitis
KW - Wegener's granulomatosis
UR - http://www.scopus.com/inward/record.url?scp=77949378800&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949378800&partnerID=8YFLogxK
M3 - Articolo
C2 - 20391682
AN - SCOPUS:77949378800
VL - 101
SP - 16
EP - 26
JO - Recenti Progressi in Medicina
JF - Recenti Progressi in Medicina
SN - 0034-1193
IS - 1
ER -