Frequency and determinants of lymphadenectomy in endometrial carcinoma: A population-based study from northern Italy

Andrea Amadori, Lauro Bucchi, Gianfranco Gori, Fabio Falcini, Luca Saragoni, Dino Amadori

Research output: Contribution to journalArticle

Abstract

Background: The diffusion of pelvic and para-aortic lymphadenectomy for the surgical pathological staging of endometrial carcinoma into clinical practice has been evaluated only with questionnaire surveys of gynecological oncologists. No population-based information is available. Methods: In this study of operable endometrial carcinoma cases registered by the population-based Romagna Cancer Registry (northern Italy) between 1987 and 1994, the association of demographic (age, time period, place of birth, place of residence, place of treatment, and marital status) and pathological factors (histological type, tumor grade, myoinvasion, and extension of disease to cervix, serosa, adnexa, and vagina) with the probability of lymphadenectomy was evaluated by multiple logistic regression analysis. Results: Of the 300 potentially eligible cases, sufficient information was obtained for 276 (92%; median age, 63 years; range, 33-87 years). No case of para-aortic lymphadenectomy was observed. Pelvic lymphadenectomy was performed in 86 (31%) cases. The probability of pelvic lymphadenectomy was related to tumor grade (positive association), place of treatment, and marital status. All other variables, including myoinvasion and extension of disease to the cervix and beyond the uterus, had no effect whatsoever. Conclusions: The most likely interpretations of results include poor acceptance of current surgical pathological staging criteria and insufficient use of standard diagnostic techniques for preoperative and intraoperative assessment of myoinvasion and extrauterine spread.

Original languageEnglish
Pages (from-to)723-728
Number of pages6
JournalAnnals of Surgical Oncology
Volume8
Issue number9
DOIs
Publication statusPublished - 2001

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Endometrial Neoplasms
Lymph Node Excision
Italy
Population
Marital Status
Uterine Cervical Diseases
Serous Membrane
Neoplasms
Vagina
Cervix Uteri
Registries
Logistic Models
Regression Analysis
Demography
Therapeutics

Keywords

  • Endometrial carcinoma
  • Lymphadenectomy
  • Myoinvasion
  • Staging
  • Tumor grade

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Frequency and determinants of lymphadenectomy in endometrial carcinoma : A population-based study from northern Italy. / Amadori, Andrea; Bucchi, Lauro; Gori, Gianfranco; Falcini, Fabio; Saragoni, Luca; Amadori, Dino.

In: Annals of Surgical Oncology, Vol. 8, No. 9, 2001, p. 723-728.

Research output: Contribution to journalArticle

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abstract = "Background: The diffusion of pelvic and para-aortic lymphadenectomy for the surgical pathological staging of endometrial carcinoma into clinical practice has been evaluated only with questionnaire surveys of gynecological oncologists. No population-based information is available. Methods: In this study of operable endometrial carcinoma cases registered by the population-based Romagna Cancer Registry (northern Italy) between 1987 and 1994, the association of demographic (age, time period, place of birth, place of residence, place of treatment, and marital status) and pathological factors (histological type, tumor grade, myoinvasion, and extension of disease to cervix, serosa, adnexa, and vagina) with the probability of lymphadenectomy was evaluated by multiple logistic regression analysis. Results: Of the 300 potentially eligible cases, sufficient information was obtained for 276 (92{\%}; median age, 63 years; range, 33-87 years). No case of para-aortic lymphadenectomy was observed. Pelvic lymphadenectomy was performed in 86 (31{\%}) cases. The probability of pelvic lymphadenectomy was related to tumor grade (positive association), place of treatment, and marital status. All other variables, including myoinvasion and extension of disease to the cervix and beyond the uterus, had no effect whatsoever. Conclusions: The most likely interpretations of results include poor acceptance of current surgical pathological staging criteria and insufficient use of standard diagnostic techniques for preoperative and intraoperative assessment of myoinvasion and extrauterine spread.",
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T1 - Frequency and determinants of lymphadenectomy in endometrial carcinoma

T2 - A population-based study from northern Italy

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AU - Saragoni, Luca

AU - Amadori, Dino

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KW - Staging

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