Abstract
A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.
Original language | English |
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Pages (from-to) | 251-253 |
Number of pages | 3 |
Journal | Tissue Antigens |
Volume | 20 |
Issue number | 4 |
Publication status | Published - 1982 |
ASJC Scopus subject areas
- Immunology
- Cell Biology