Frequency and prognostic value of HLA antigens in osteosarcoma patients

P. Tabacchi, M. Chiricolo, M. Cenci, F. Barboni, M. Manfrini, G. Bacci, P. Picci, M. Campanacci, F. Licastro, C. Franceschi

Research output: Contribution to journalArticlepeer-review


A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.

Original languageEnglish
Pages (from-to)251-253
Number of pages3
JournalTissue Antigens
Issue number4
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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