Abstract
A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.
| Original language | English |
|---|---|
| Pages (from-to) | 251-253 |
| Number of pages | 3 |
| Journal | Tissue Antigens |
| Volume | 20 |
| Issue number | 4 |
| Publication status | Published - 1982 |
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ASJC Scopus subject areas
- Immunology
- Cell Biology
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Frequency and prognostic value of HLA antigens in osteosarcoma patients. / Tabacchi, P.; Chiricolo, M.; Cenci, M.; Barboni, F.; Manfrini, M.; Bacci, G.; Picci, P.; Campanacci, M.; Licastro, F.; Franceschi, C.
In: Tissue Antigens, Vol. 20, No. 4, 1982, p. 251-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequency and prognostic value of HLA antigens in osteosarcoma patients
AU - Tabacchi, P.
AU - Chiricolo, M.
AU - Cenci, M.
AU - Barboni, F.
AU - Manfrini, M.
AU - Bacci, G.
AU - Picci, P.
AU - Campanacci, M.
AU - Licastro, F.
AU - Franceschi, C.
PY - 1982
Y1 - 1982
N2 - A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.
AB - A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.
UR - http://www.scopus.com/inward/record.url?scp=0019948828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019948828&partnerID=8YFLogxK
M3 - Article
C2 - 6983158
AN - SCOPUS:0019948828
VL - 20
SP - 251
EP - 253
JO - Tissue Antigens
JF - Tissue Antigens
SN - 0001-2815
IS - 4
ER -