Frequency and prognostic value of HLA antigens in osteosarcoma patients

P. Tabacchi; M. Chiricolo; M. Cenci; F. Barboni; M. Manfrini; G. Bacci; P. Picci; M. Campanacci; F. Licastro; C. Franceschi

Frequency and prognostic value of HLA antigens in osteosarcoma patients

P. Tabacchi, M. Chiricolo, M. Cenci, F. Barboni, M. Manfrini, G. Bacci, P. Picci, M. Campanacci, F. Licastro, C. Franceschi

Research output: Contribution to journal › Article › peer-review

Abstract

A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.

Original language	English
Pages (from-to)	251-253
Number of pages	3
Journal	Tissue Antigens
Volume	20
Issue number	4
Publication status	Published - 1982

ASJC Scopus subject areas

Immunology
Cell Biology

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title = "Frequency and prognostic value of HLA antigens in osteosarcoma patients",

abstract = "A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.",

author = "P. Tabacchi and M. Chiricolo and M. Cenci and F. Barboni and M. Manfrini and G. Bacci and P. Picci and M. Campanacci and F. Licastro and C. Franceschi",

year = "1982",

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T1 - Frequency and prognostic value of HLA antigens in osteosarcoma patients

AU - Tabacchi, P.

AU - Chiricolo, M.

AU - Cenci, M.

AU - Barboni, F.

AU - Manfrini, M.

AU - Bacci, G.

AU - Picci, P.

AU - Campanacci, M.

AU - Licastro, F.

AU - Franceschi, C.

PY - 1982

Y1 - 1982

N2 - A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.

AB - A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.

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