Abstract
The rates of non-albicans species and susceptibility to the main antimycotic drugs were evaluated in a series of 472 cultures of vulvar or vaginal specimens positive for Candida species. Torulopsis glabrata was associated more frequently than C. albicans with recurrent vulvovaginal candidiasis (18/40 vs. 72/379; p = 0.003, X2 test). As evaluated by the results of susceptibility testing, C. albicans isolates were uniformly sensitive to the antifungals tested, whereas 7.5% (3/40) of T. glabrata strains were resistant to imidazole derivatives. All these patients had a history of repeated antimycotic treatments. Previous antimycotic therapies in susceptible individuals could cause a selection of non- albicans species, especially T. glabrata, which is occasionally resistant to the commonly used antimycoticdrugs.
| Original language | English |
|---|---|
| Pages (from-to) | 130-133 |
| Number of pages | 4 |
| Journal | Gynecologic and Obstetric Investigation |
| Volume | 38 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1994 |
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Keywords
- Candida albicans
- Dresistance
- Torulopsis glabrata
- Vulvovaginitis drug
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine
Cite this
Frequency and significance of drug resistance in vulvovaginal candidiasis. / Spinillo, Arsenio; Nicola, Sabrina; Colonna, Laura; Marangoni, Emanuela; Cavanna, Caterina; Michelone, Giuseppe.
In: Gynecologic and Obstetric Investigation, Vol. 38, No. 2, 1994, p. 130-133.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequency and significance of drug resistance in vulvovaginal candidiasis
AU - Spinillo, Arsenio
AU - Nicola, Sabrina
AU - Colonna, Laura
AU - Marangoni, Emanuela
AU - Cavanna, Caterina
AU - Michelone, Giuseppe
PY - 1994
Y1 - 1994
N2 - The rates of non-albicans species and susceptibility to the main antimycotic drugs were evaluated in a series of 472 cultures of vulvar or vaginal specimens positive for Candida species. Torulopsis glabrata was associated more frequently than C. albicans with recurrent vulvovaginal candidiasis (18/40 vs. 72/379; p = 0.003, X2 test). As evaluated by the results of susceptibility testing, C. albicans isolates were uniformly sensitive to the antifungals tested, whereas 7.5% (3/40) of T. glabrata strains were resistant to imidazole derivatives. All these patients had a history of repeated antimycotic treatments. Previous antimycotic therapies in susceptible individuals could cause a selection of non- albicans species, especially T. glabrata, which is occasionally resistant to the commonly used antimycoticdrugs.
AB - The rates of non-albicans species and susceptibility to the main antimycotic drugs were evaluated in a series of 472 cultures of vulvar or vaginal specimens positive for Candida species. Torulopsis glabrata was associated more frequently than C. albicans with recurrent vulvovaginal candidiasis (18/40 vs. 72/379; p = 0.003, X2 test). As evaluated by the results of susceptibility testing, C. albicans isolates were uniformly sensitive to the antifungals tested, whereas 7.5% (3/40) of T. glabrata strains were resistant to imidazole derivatives. All these patients had a history of repeated antimycotic treatments. Previous antimycotic therapies in susceptible individuals could cause a selection of non- albicans species, especially T. glabrata, which is occasionally resistant to the commonly used antimycoticdrugs.
KW - Candida albicans
KW - Dresistance
KW - Torulopsis glabrata
KW - Vulvovaginitis drug
UR - http://www.scopus.com/inward/record.url?scp=0027935663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027935663&partnerID=8YFLogxK
U2 - 10.1159/000292465
DO - 10.1159/000292465
M3 - Article
C2 - 7959341
AN - SCOPUS:0027935663
VL - 38
SP - 130
EP - 133
JO - Gynecologic and Obstetric Investigation
JF - Gynecologic and Obstetric Investigation
SN - 0378-7346
IS - 2
ER -