Frequency and significance of drug resistance in vulvovaginal candidiasis

Arsenio Spinillo, Sabrina Nicola, Laura Colonna, Emanuela Marangoni, Caterina Cavanna, Giuseppe Michelone

Research output: Contribution to journalArticlepeer-review


The rates of non-albicans species and susceptibility to the main antimycotic drugs were evaluated in a series of 472 cultures of vulvar or vaginal specimens positive for Candida species. Torulopsis glabrata was associated more frequently than C. albicans with recurrent vulvovaginal candidiasis (18/40 vs. 72/379; p = 0.003, X2 test). As evaluated by the results of susceptibility testing, C. albicans isolates were uniformly sensitive to the antifungals tested, whereas 7.5% (3/40) of T. glabrata strains were resistant to imidazole derivatives. All these patients had a history of repeated antimycotic treatments. Previous antimycotic therapies in susceptible individuals could cause a selection of non- albicans species, especially T. glabrata, which is occasionally resistant to the commonly used antimycoticdrugs.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalGynecologic and Obstetric Investigation
Issue number2
Publication statusPublished - 1994


  • Candida albicans
  • Dresistance
  • Torulopsis glabrata
  • Vulvovaginitis drug

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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