Frequency, clinical and laboratory features of thyroiditis in girls with Turner's syndrome

G. Radetti, L. Mazzanti, C. Paganini, S. Bernasconi, G. Russo, F. Rigon, E. Cacciari

Research output: Contribution to journalArticlepeer-review

Abstract

A total of 478 patients, mean age 15.5 (3.6-25.3) years, suffering from Turner's syndrome, were studied in order to determine the frequency of autoimmune thyroiditis, which is defined as the presence of antithyroid antibodies (AT-Ab) and typical ultrasound findings. We found 106 (22.2%) patients positive for AT-Ab and of those 49 (10%) also had positive ultrasound findings, and were therefore considered to be affected by thyroiditis. This frequency is significantly higher (p <0.001) than that seen in the normal population. Goitre was detected on clinical examination in only 16 (33%) and by ultrasound in 19 (39%) patients. Hormonal evaluation showed that 17 patients were euthyroid, 27 had compensated hypothyroidism, 2 were hypothyroid and 3 were in a hyperthyroid phase. Clinical signs or symptoms of hypothyroidism were absent in all hypothyroid patients. In patients with thyroiditis, neither a higher frequency of malformations and autoimmune diseases nor a correlation with karyotype, oestrogens or growth hormone therapy was found.

Original languageEnglish
Pages (from-to)909-912
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume84
Issue number8
Publication statusPublished - 1995

Keywords

  • Antithyroid antibodies
  • Thyroid hormones
  • Thyroid ultrasound
  • Thyroiditis
  • Turner's syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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