Frequency, Determinants, and Clinical Relevance of Acute Coronary Syndrome-Like Electrocardiographic Findings in Patients With Acute Aortic Syndrome

Elena Biagini, Carla Lofiego, Marinella Ferlito, Rossella Fattori, Guido Rocchi, Maddalena Graziosi, Luigi Lovato, Lara di Diodoro, Robin M T Cooke, Elisabetta Petracci, Letizia Bacchi-Reggiani, Romano Zannoli, Angelo Branzi, Claudio Rapezzi

Research output: Contribution to journalArticle

Abstract

We investigated frequency/characteristics of acute coronary syndrome-like (ACS-like) electrocardiographic (ECG) profiles among patients with a final diagnosis of acute aortic syndrome (AAS), and explored pathophysiologic determinants and prognostic relevance within each Stanford subtype. We blindly reviewed presentation electrocardiograms of 233 consecutive patients with final diagnosis of AAS (164 Stanford type A) at a regional treatment center. Prevalence of ACS-like ECG findings was 27% (type A, 26%, type B, 29%); most were non-ST-elevation myocardial infarction-like. Patients with ACS-like ECG findings more often had coronary ostia involvement (p = 0.002), pleural effusion (p = 0.02), significant aortic regurgitation (p = 0.01), and troponin positivity (p = 0.001). ACS-like ECG profile in type A disease was independently associated with coronary ostia involvement (odds ratio [OR] 5.27, 95% confidence interval [CI] 1.75 to 15.88). ACS-like ECG profile predicted in-hospital mortality (OR 2.90, 95% CI 1.24 to 6.12), as did age (each incremental 10-year: OR 1.59, 95% CI 1.14 to 2.22), and syncope at presentation (OR 2.90, 95% CI 1.16 to 7.24). In conclusion, about 25% of our AAS patients (in either Stanford subtype) presented ACS-like ECG patterns-often with non-ST-elevation myocardial infarction characteristics-which could cause misdiagnosis. ACS-like ECG profile was associated with more complicated disease, and in type A disease was a strong independent predictor of in-hospital mortality.

Original languageEnglish
Pages (from-to)1013-1019
Number of pages7
JournalThe American Journal of Cardiology
Volume100
Issue number6
DOIs
Publication statusPublished - Sep 15 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Biagini, E., Lofiego, C., Ferlito, M., Fattori, R., Rocchi, G., Graziosi, M., Lovato, L., di Diodoro, L., Cooke, R. M. T., Petracci, E., Bacchi-Reggiani, L., Zannoli, R., Branzi, A., & Rapezzi, C. (2007). Frequency, Determinants, and Clinical Relevance of Acute Coronary Syndrome-Like Electrocardiographic Findings in Patients With Acute Aortic Syndrome. The American Journal of Cardiology, 100(6), 1013-1019. https://doi.org/10.1016/j.amjcard.2007.04.044