TY - JOUR
T1 - Frequency-modulated electromagnetic neural stimulation (FREMS) as a treatment for symptomatic diabetic neuropathy
T2 - Results from a double-blind, randomised, multicentre, long-term, placebo-controlled clinical trial
AU - Bosi, E.
AU - Bax, G.
AU - Scionti, L.
AU - Spallone, V.
AU - Tesfaye, S.
AU - Valensi, P.
AU - Ziegler, D.
PY - 2013/3
Y1 - 2013/3
N2 - Aims/hypothesis: The aim was to evaluate the efficacy and safety of transcutaneous frequency-modulated electromagnetic neural stimulation (frequency rhythmic electrical modulation system, FREMS) as a treatment for symptomatic peripheral neuropathy in patients with diabetes mellitus. Methods: This was a double-blind, randomised, multicentre, parallel-group study of three series, each of ten treatment sessions of FREMS or placebo administered within 3 weeks, 3 months apart, with an overall follow-up of about 51 weeks. The primary endpoint was the change in nerve conduction velocity (NCV) of deep peroneal, tibial and sural nerves. Secondary endpoints included the effects of treatment on pain, tactile, thermal and vibration sensations. Patients eligible to participate were aged 18-75 years with diabetes for ≥1 year, HbA1c
AB - Aims/hypothesis: The aim was to evaluate the efficacy and safety of transcutaneous frequency-modulated electromagnetic neural stimulation (frequency rhythmic electrical modulation system, FREMS) as a treatment for symptomatic peripheral neuropathy in patients with diabetes mellitus. Methods: This was a double-blind, randomised, multicentre, parallel-group study of three series, each of ten treatment sessions of FREMS or placebo administered within 3 weeks, 3 months apart, with an overall follow-up of about 51 weeks. The primary endpoint was the change in nerve conduction velocity (NCV) of deep peroneal, tibial and sural nerves. Secondary endpoints included the effects of treatment on pain, tactile, thermal and vibration sensations. Patients eligible to participate were aged 18-75 years with diabetes for ≥1 year, HbA1c
KW - Diabetic neuropathy
KW - Electrical stimulation
KW - Nerve conduction studies
KW - Neuropathic pain
KW - Neurostimulation therapy
KW - Randomised clinical trial
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U2 - 10.1007/s00125-012-2795-7
DO - 10.1007/s00125-012-2795-7
M3 - Article
C2 - 23238789
AN - SCOPUS:84878357336
VL - 56
SP - 467
EP - 475
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 3
ER -