Frequency of a mutated CCR-5 allele (Δ32) among Italian healthy donors and individuals at risk of parenteral HIV infection

Rita Zamarchi, Stefano Indraccolo, Sonia Minuzzo, Vincenzo Coppola, Alessandro Gringeri, Elena Santagostino, Elisa Vicenzi, Giustina De Silvestro, Roberta Biagiotti, Clara Baldassarre, Luigi Chieco-Bianchi, Alberto Amadori

Research output: Contribution to journalArticle

Abstract

The aim of this study was to assess the frequency of a truncated allele of the CCR-5 gene (Δ32) in Italy, and address its possible role in parenteral HIV transmission, as well as its influence in HIV-associated disease progression. In 371 unrelated seronegative healthy blood donors the Δ32 allele frequency was 0.047; this figure was significantly different from those reported in northern America and northern Europe populations. However, Δ32 allele frequency in healthy individuals did not differ significantly from that found in 54 seronegative drug users (0.065), 98 seronegative hemophiliacs (0.051), and 81 seropositive hemophiliacs (0.049). Although in seropositive hemophiliacs the wt/Δ32 heterozygous genotype was associated with a trend to a slower decline in CD4+ cell counts, its presence did not seem to influence disease progression, as comparable Δ32 allele frequency frequencies were found among progressing (0.042) and nonprogressing (0.111) patients. These data do not seem to support a protective role of the Δ32 allele in preventing HIV infection through the parenteral route, or in influencing the natural history of the disease in this particular risk category, although the Δ32 heterozygous state was associated with lower plasma viremia levels. On the other hand, the finding of non-syncytium- inducing HIV strains in the majority of Δ32 heterozygous seropositive patients suggests that its presence could not be a major factor in driving a switch toward more cytopathic, T-tropic HIV strains through selective pressure in coreceptor usage.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume15
Issue number4
DOIs
Publication statusPublished - Mar 1 1999

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HIV Infections
Alleles
Gene Frequency
Tissue Donors
HIV
Disease Progression
Viremia
CD4 Lymphocyte Count
North America
Drug Users
Blood Donors
Italy
Genotype
Population
Genes

ASJC Scopus subject areas

  • Immunology
  • Virology

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Frequency of a mutated CCR-5 allele (Δ32) among Italian healthy donors and individuals at risk of parenteral HIV infection. / Zamarchi, Rita; Indraccolo, Stefano; Minuzzo, Sonia; Coppola, Vincenzo; Gringeri, Alessandro; Santagostino, Elena; Vicenzi, Elisa; De Silvestro, Giustina; Biagiotti, Roberta; Baldassarre, Clara; Chieco-Bianchi, Luigi; Amadori, Alberto.

In: AIDS Research and Human Retroviruses, Vol. 15, No. 4, 01.03.1999, p. 337-344.

Research output: Contribution to journalArticle

Zamarchi, Rita ; Indraccolo, Stefano ; Minuzzo, Sonia ; Coppola, Vincenzo ; Gringeri, Alessandro ; Santagostino, Elena ; Vicenzi, Elisa ; De Silvestro, Giustina ; Biagiotti, Roberta ; Baldassarre, Clara ; Chieco-Bianchi, Luigi ; Amadori, Alberto. / Frequency of a mutated CCR-5 allele (Δ32) among Italian healthy donors and individuals at risk of parenteral HIV infection. In: AIDS Research and Human Retroviruses. 1999 ; Vol. 15, No. 4. pp. 337-344.
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AU - Indraccolo, Stefano

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AU - Coppola, Vincenzo

AU - Gringeri, Alessandro

AU - Santagostino, Elena

AU - Vicenzi, Elisa

AU - De Silvestro, Giustina

AU - Biagiotti, Roberta

AU - Baldassarre, Clara

AU - Chieco-Bianchi, Luigi

AU - Amadori, Alberto

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