Frequency of Acentric Fragments Are Associated with Cancer Risk in Subjects Exposed to Ionizing Radiation

Aleksandra Fucic, Stefano Bonassi, Sarolta Gundy, Juozas Lazutka, Radim J. Sram, Marcello Ceppi, Joe N. Lucas

Research output: Contribution to journalArticle

Abstract

BACKGROUND/AIM: Biomonitoring is currently applied in the estimation of health risks after overexposure to ionizing radiation (IR). The aim of this study was to compare the association of dicentric chromosomes and acentric fragments (AF) with cancer risk in subjects exposed to IR, as well as in control subjects.MATERIALS AND METHODS: The study was performed on 3,574 subjects (2,030 subjects exposed to IR and 1,544 control subjects). The mean follow-up period was 8 years.RESULTS: In subjects reporting exposure to IR, the presence of AFs and dicentric chromosomes was associated with a significant increase in cancer risk, hazard ratio (HR)=1.78 (95% confidence interval (CI)=1.01-3.13) and HR=1.73 (95% CI=1.03-2.90), respectively.CONCLUSION: AFs are associated with cancer risk and have a similar sensitivity to dicentric chromosomes in subjects exposed to IR. Because automated AF scoring can be easily introduced using fast flow cytometry combined with the pan-centromere staining, this biomarker may hold promise as a potential sensitive biomarker of exposure to IR and cancer risk.
Original languageEnglish
Pages (from-to)2451-2457
Number of pages7
JournalAnticancer Research
Volume36
Issue number5
Publication statusPublished - May 2016

Keywords

  • Chromosome Aberrations
  • Genetic Predisposition to Disease
  • Humans
  • Neoplasms, Radiation-Induced
  • Radiation, Ionizing
  • Journal Article

Fingerprint Dive into the research topics of 'Frequency of Acentric Fragments Are Associated with Cancer Risk in Subjects Exposed to Ionizing Radiation'. Together they form a unique fingerprint.

Cite this