Frequency of bcl-2/IgH translocation in patients with non-Hodgkin's lymphoma and chronic hepatitis C virus infection

M. Libra, V. De Re, A. Gloghini, D. Callari, G. Malaponte, S. Travali, M. C. Mazzarino, F. Stivala, M. Boiocchi, A. Carbone

Research output: Contribution to journalArticlepeer-review

Abstract

Aim. It has been previously suggested that t(14;18) translocation of bcl-2 to the immunoglobulin heavy chain (IgH) locus may contribute to pathogenesis of lymphoproliferative disorders related to hepatitis C virus (HCV) infection, including type II mixed cryoglobulinemia (MC). Methods. In this study, the presence or absence of t(14;18) translocation was determined in tumor biopsy specimens and peripheral blood mononuclear cells (PBMCs) for 48 NHL patients with chronic HCV infection. Results. In tumor biopsy specimens from 32 HCV-positive NHL patients, bcl-2/IgH translocation was detected in 1 of 13 patients with MC syndrome (7.7%) and 3 of 19 patients without MC syndrome (15.8%). In PBMCs from 23 HCV-positive NHL patients, this translocation was observed in 3 of 6 patients with MC syndrome (50%) and 4 of 17 patients without MC syndrome (23.5%). Interestingly, bcl-2/IgH translocation was found in 2 extranodal marginal zone B-cell lymphoma tissues from HCV-infected patients. Conclusion. However, additional studies are required to better clarify the relationship between this translocation and extranodal marginal zone B-cell lymphoma development. Although the frequency of bcl-2/IgH translocation in PBMCs from patients with chronic HCV infection is higher than that of other NHL patients, this increased translocation rate remains to be elucidated.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalMinerva Gastroenterologica e Dietologica
Volume51
Issue number2
Publication statusPublished - 2005

Keywords

  • Hepatitis C
  • Lymphoma, non Hodgkins
  • Translocation

ASJC Scopus subject areas

  • Gastroenterology

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