Abstract
Aim. It has been previously suggested that t(14;18) translocation of bcl-2 to the immunoglobulin heavy chain (IgH) locus may contribute to pathogenesis of lymphoproliferative disorders related to hepatitis C virus (HCV) infection, including type II mixed cryoglobulinemia (MC). Methods. In this study, the presence or absence of t(14;18) translocation was determined in tumor biopsy specimens and peripheral blood mononuclear cells (PBMCs) for 48 NHL patients with chronic HCV infection. Results. In tumor biopsy specimens from 32 HCV-positive NHL patients, bcl-2/IgH translocation was detected in 1 of 13 patients with MC syndrome (7.7%) and 3 of 19 patients without MC syndrome (15.8%). In PBMCs from 23 HCV-positive NHL patients, this translocation was observed in 3 of 6 patients with MC syndrome (50%) and 4 of 17 patients without MC syndrome (23.5%). Interestingly, bcl-2/IgH translocation was found in 2 extranodal marginal zone B-cell lymphoma tissues from HCV-infected patients. Conclusion. However, additional studies are required to better clarify the relationship between this translocation and extranodal marginal zone B-cell lymphoma development. Although the frequency of bcl-2/IgH translocation in PBMCs from patients with chronic HCV infection is higher than that of other NHL patients, this increased translocation rate remains to be elucidated.
| Original language | English |
|---|---|
| Pages (from-to) | 165-170 |
| Number of pages | 6 |
| Journal | Minerva Gastroenterologica e Dietologica |
| Volume | 51 |
| Issue number | 2 |
| Publication status | Published - 2005 |
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Keywords
- Hepatitis C
- Lymphoma, non Hodgkins
- Translocation
ASJC Scopus subject areas
- Gastroenterology
Cite this
Frequency of bcl-2/IgH translocation in patients with non-Hodgkin's lymphoma and chronic hepatitis C virus infection. / Libra, M.; De Re, V.; Gloghini, A.; Callari, D.; Malaponte, G.; Travali, S.; Mazzarino, M. C.; Stivala, F.; Boiocchi, M.; Carbone, A.
In: Minerva Gastroenterologica e Dietologica, Vol. 51, No. 2, 2005, p. 165-170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequency of bcl-2/IgH translocation in patients with non-Hodgkin's lymphoma and chronic hepatitis C virus infection
AU - Libra, M.
AU - De Re, V.
AU - Gloghini, A.
AU - Callari, D.
AU - Malaponte, G.
AU - Travali, S.
AU - Mazzarino, M. C.
AU - Stivala, F.
AU - Boiocchi, M.
AU - Carbone, A.
PY - 2005
Y1 - 2005
N2 - Aim. It has been previously suggested that t(14;18) translocation of bcl-2 to the immunoglobulin heavy chain (IgH) locus may contribute to pathogenesis of lymphoproliferative disorders related to hepatitis C virus (HCV) infection, including type II mixed cryoglobulinemia (MC). Methods. In this study, the presence or absence of t(14;18) translocation was determined in tumor biopsy specimens and peripheral blood mononuclear cells (PBMCs) for 48 NHL patients with chronic HCV infection. Results. In tumor biopsy specimens from 32 HCV-positive NHL patients, bcl-2/IgH translocation was detected in 1 of 13 patients with MC syndrome (7.7%) and 3 of 19 patients without MC syndrome (15.8%). In PBMCs from 23 HCV-positive NHL patients, this translocation was observed in 3 of 6 patients with MC syndrome (50%) and 4 of 17 patients without MC syndrome (23.5%). Interestingly, bcl-2/IgH translocation was found in 2 extranodal marginal zone B-cell lymphoma tissues from HCV-infected patients. Conclusion. However, additional studies are required to better clarify the relationship between this translocation and extranodal marginal zone B-cell lymphoma development. Although the frequency of bcl-2/IgH translocation in PBMCs from patients with chronic HCV infection is higher than that of other NHL patients, this increased translocation rate remains to be elucidated.
AB - Aim. It has been previously suggested that t(14;18) translocation of bcl-2 to the immunoglobulin heavy chain (IgH) locus may contribute to pathogenesis of lymphoproliferative disorders related to hepatitis C virus (HCV) infection, including type II mixed cryoglobulinemia (MC). Methods. In this study, the presence or absence of t(14;18) translocation was determined in tumor biopsy specimens and peripheral blood mononuclear cells (PBMCs) for 48 NHL patients with chronic HCV infection. Results. In tumor biopsy specimens from 32 HCV-positive NHL patients, bcl-2/IgH translocation was detected in 1 of 13 patients with MC syndrome (7.7%) and 3 of 19 patients without MC syndrome (15.8%). In PBMCs from 23 HCV-positive NHL patients, this translocation was observed in 3 of 6 patients with MC syndrome (50%) and 4 of 17 patients without MC syndrome (23.5%). Interestingly, bcl-2/IgH translocation was found in 2 extranodal marginal zone B-cell lymphoma tissues from HCV-infected patients. Conclusion. However, additional studies are required to better clarify the relationship between this translocation and extranodal marginal zone B-cell lymphoma development. Although the frequency of bcl-2/IgH translocation in PBMCs from patients with chronic HCV infection is higher than that of other NHL patients, this increased translocation rate remains to be elucidated.
KW - Hepatitis C
KW - Lymphoma, non Hodgkins
KW - Translocation
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M3 - Article
VL - 51
SP - 165
EP - 170
JO - Minerva Gastroenterologica
JF - Minerva Gastroenterologica
SN - 0026-4776
IS - 2
ER -