Frequency of familial gastric cancer

Giovanni Corso, Daniele Marrelli

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

About 80-90 % of gastric cancer appears as sporadic form, and 10-20 % with a familial setting; however, considering the different worldwide countries, this frequency appears extremely variable. In high risk-area for gastric tumors this incidence results higher than in low-risk zones. Conversely, the frequency of CDH1 germline mutations is contrasting with the incidence of familial gastric carcinoma. Exploring these considerations, in high-risk area it seems that environmental factors exercise a stronger mechanism in the familial gastric carcinogenesis. This data could open new approaches in the gastric cancer prevention test; before to candidate a proband for the CDH1 genetic screening, geographic variability, alongside the family history should be considered.

Original languageEnglish
Title of host publicationSpotlight on Familial and Hereditary Gastric Cancer
PublisherSpringer Netherlands
Pages11-18
Number of pages8
ISBN (Print)9789400765702, 940076569X, 9789400765696
DOIs
Publication statusPublished - Feb 1 2013

Keywords

  • Cancer risk
  • CDH1 gene
  • High and low incidences
  • Population frequency

ASJC Scopus subject areas

  • Medicine(all)

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