Abstract
About 80-90 % of gastric cancer appears as sporadic form, and 10-20 % with a familial setting; however, considering the different worldwide countries, this frequency appears extremely variable. In high risk-area for gastric tumors this incidence results higher than in low-risk zones. Conversely, the frequency of CDH1 germline mutations is contrasting with the incidence of familial gastric carcinoma. Exploring these considerations, in high-risk area it seems that environmental factors exercise a stronger mechanism in the familial gastric carcinogenesis. This data could open new approaches in the gastric cancer prevention test; before to candidate a proband for the CDH1 genetic screening, geographic variability, alongside the family history should be considered.
Original language | English |
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Title of host publication | Spotlight on Familial and Hereditary Gastric Cancer |
Publisher | Springer Netherlands |
Pages | 11-18 |
Number of pages | 8 |
ISBN (Print) | 9789400765702, 940076569X, 9789400765696 |
DOIs | |
Publication status | Published - Feb 1 2013 |
Keywords
- Cancer risk
- CDH1 gene
- High and low incidences
- Population frequency
ASJC Scopus subject areas
- Medicine(all)