Frequency of familial gastric cancer

Giovanni Corso; Daniele Marrelli

doi:10.1007/978-94-007-6570-2_2

Frequency of familial gastric cancer

Giovanni Corso, Daniele Marrelli

Istituto Europeo di Oncologia

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

About 80-90 % of gastric cancer appears as sporadic form, and 10-20 % with a familial setting; however, considering the different worldwide countries, this frequency appears extremely variable. In high risk-area for gastric tumors this incidence results higher than in low-risk zones. Conversely, the frequency of CDH1 germline mutations is contrasting with the incidence of familial gastric carcinoma. Exploring these considerations, in high-risk area it seems that environmental factors exercise a stronger mechanism in the familial gastric carcinogenesis. This data could open new approaches in the gastric cancer prevention test; before to candidate a proband for the CDH1 genetic screening, geographic variability, alongside the family history should be considered.

Original language	English
Title of host publication	Spotlight on Familial and Hereditary Gastric Cancer
Publisher	Springer Netherlands
Pages	11-18
Number of pages	8
ISBN (Print)	9789400765702, 940076569X, 9789400765696
DOIs	https://doi.org/10.1007/978-94-007-6570-2_2
Publication status	Published - Feb 1 2013

Keywords

Cancer risk
CDH1 gene
High and low incidences
Population frequency

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-94-007-6570-2_2

Cite this

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AB - About 80-90 % of gastric cancer appears as sporadic form, and 10-20 % with a familial setting; however, considering the different worldwide countries, this frequency appears extremely variable. In high risk-area for gastric tumors this incidence results higher than in low-risk zones. Conversely, the frequency of CDH1 germline mutations is contrasting with the incidence of familial gastric carcinoma. Exploring these considerations, in high-risk area it seems that environmental factors exercise a stronger mechanism in the familial gastric carcinogenesis. This data could open new approaches in the gastric cancer prevention test; before to candidate a proband for the CDH1 genetic screening, geographic variability, alongside the family history should be considered.

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Frequency of familial gastric cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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