Frequency of familial gastric cancer

Giovanni Corso, Daniele Marrelli

Research output: Chapter in Book/Report/Conference proceedingChapter


About 80-90 % of gastric cancer appears as sporadic form, and 10-20 % with a familial setting; however, considering the different worldwide countries, this frequency appears extremely variable. In high risk-area for gastric tumors this incidence results higher than in low-risk zones. Conversely, the frequency of CDH1 germline mutations is contrasting with the incidence of familial gastric carcinoma. Exploring these considerations, in high-risk area it seems that environmental factors exercise a stronger mechanism in the familial gastric carcinogenesis. This data could open new approaches in the gastric cancer prevention test; before to candidate a proband for the CDH1 genetic screening, geographic variability, alongside the family history should be considered.

Original languageEnglish
Title of host publicationSpotlight on Familial and Hereditary Gastric Cancer
PublisherSpringer Netherlands
Number of pages8
ISBN (Print)9789400765702, 940076569X, 9789400765696
Publication statusPublished - Feb 1 2013


  • Cancer risk
  • CDH1 gene
  • High and low incidences
  • Population frequency

ASJC Scopus subject areas

  • Medicine(all)


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