Abstract
Circulating and bound IgA antibodies can be found in the autoimmune blistering diseases, but their prevalence, clinical relevance and target antigens remain unknown. Thirty-two patients with pemphigus, 73 with bullous pemphigoid and 28 with mucous membrane pemphigoid were studied retrospectively. Direct immunofluorescence (DIF) analysis of IgG, IgA, IgM and C3 was carried out For all cases. Sera were studied by standard indirect immunofluorescence, indirect immunofluorescence on salt-split skin, immunoblotting for bullous pemphigoid and mucous membrane pemphigoid and ELISA for pemphigus. With DIF, we found IgA autoantibodies in 22 of all 133 cases. Circulating IgA antibodies to skin were detected in 2 of 3 IgA-DIF-positive patients with pemphigus, in 3 of 6 with bullous pemphigoid, and in 6 of 13 with mucous membrane pemphigoid. We confirm that the IgA reactivity is more frequently associated with mucous membrane involvement, especially in cases without critical involvement (5/8). The role of IgA and its antigenic specificity in these diseases remain unclear.
| Original language | English |
|---|---|
| Pages (from-to) | 381-384 |
| Number of pages | 4 |
| Journal | Acta Dermato-Venereologica |
| Volume | 84 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2004 |
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Keywords
- Bullous pemphigoid
- IgA
- Mucous membrane pemphigoid
- Pemphigus
ASJC Scopus subject areas
- Dermatology
Cite this
Frequency of IgA antibodies in pemphigus, bullous pemphigoid and mucous membrane pemphigoid. / Cozzani, Emanuele; Drosera, Massimo; Parodi, Aurora; Carrozzo, Marco; Gandolfo, Sergio; Rebora, Alfredo.
In: Acta Dermato-Venereologica, Vol. 84, No. 5, 2004, p. 381-384.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequency of IgA antibodies in pemphigus, bullous pemphigoid and mucous membrane pemphigoid
AU - Cozzani, Emanuele
AU - Drosera, Massimo
AU - Parodi, Aurora
AU - Carrozzo, Marco
AU - Gandolfo, Sergio
AU - Rebora, Alfredo
PY - 2004
Y1 - 2004
N2 - Circulating and bound IgA antibodies can be found in the autoimmune blistering diseases, but their prevalence, clinical relevance and target antigens remain unknown. Thirty-two patients with pemphigus, 73 with bullous pemphigoid and 28 with mucous membrane pemphigoid were studied retrospectively. Direct immunofluorescence (DIF) analysis of IgG, IgA, IgM and C3 was carried out For all cases. Sera were studied by standard indirect immunofluorescence, indirect immunofluorescence on salt-split skin, immunoblotting for bullous pemphigoid and mucous membrane pemphigoid and ELISA for pemphigus. With DIF, we found IgA autoantibodies in 22 of all 133 cases. Circulating IgA antibodies to skin were detected in 2 of 3 IgA-DIF-positive patients with pemphigus, in 3 of 6 with bullous pemphigoid, and in 6 of 13 with mucous membrane pemphigoid. We confirm that the IgA reactivity is more frequently associated with mucous membrane involvement, especially in cases without critical involvement (5/8). The role of IgA and its antigenic specificity in these diseases remain unclear.
AB - Circulating and bound IgA antibodies can be found in the autoimmune blistering diseases, but their prevalence, clinical relevance and target antigens remain unknown. Thirty-two patients with pemphigus, 73 with bullous pemphigoid and 28 with mucous membrane pemphigoid were studied retrospectively. Direct immunofluorescence (DIF) analysis of IgG, IgA, IgM and C3 was carried out For all cases. Sera were studied by standard indirect immunofluorescence, indirect immunofluorescence on salt-split skin, immunoblotting for bullous pemphigoid and mucous membrane pemphigoid and ELISA for pemphigus. With DIF, we found IgA autoantibodies in 22 of all 133 cases. Circulating IgA antibodies to skin were detected in 2 of 3 IgA-DIF-positive patients with pemphigus, in 3 of 6 with bullous pemphigoid, and in 6 of 13 with mucous membrane pemphigoid. We confirm that the IgA reactivity is more frequently associated with mucous membrane involvement, especially in cases without critical involvement (5/8). The role of IgA and its antigenic specificity in these diseases remain unclear.
KW - Bullous pemphigoid
KW - IgA
KW - Mucous membrane pemphigoid
KW - Pemphigus
UR - http://www.scopus.com/inward/record.url?scp=4744367303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4744367303&partnerID=8YFLogxK
U2 - 10.1080/00015550410031825
DO - 10.1080/00015550410031825
M3 - Article
C2 - 15370705
AN - SCOPUS:4744367303
VL - 84
SP - 381
EP - 384
JO - Acta Borealia
JF - Acta Borealia
SN - 0001-5555
IS - 5
ER -