Frequency of monosomy X in women with primary biliary cirrhosis

Pietro Invernizzi, Monica Miozzo, Pier Maria Battezzati, Ilaria Bianchi, Francesca R. Grati, Giuseppe Simoni, Carlo Selmi, Mitchell Watnik, M. Eric Gershwin, Mauro Podda

Research output: Contribution to journalArticle

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Abstract

The mechanisms that cause the female predominance of primary biliary cirrhosis (PBC) are uncertain, but the X chromosome includes genes involved in immunological tolerance. We assessed the rate of X monosomy in peripheral white blood cells from 100 women with PBC, 50 with chronic hepatitis C, and 50 healthy controls, by fluorescence in-situ hybridisation. Frequency of X monosomy increased with age in all groups, but was significantly higher in women with PBC than in controls (p

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalLancet
Volume363
Issue number9408
DOIs
Publication statusPublished - Feb 14 2004

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Turner Syndrome
Biliary Liver Cirrhosis
X-Linked Genes
Chronic Hepatitis C
Fluorescence In Situ Hybridization
Leukocytes

ASJC Scopus subject areas

  • Medicine(all)

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Frequency of monosomy X in women with primary biliary cirrhosis. / Invernizzi, Pietro; Miozzo, Monica; Battezzati, Pier Maria; Bianchi, Ilaria; Grati, Francesca R.; Simoni, Giuseppe; Selmi, Carlo; Watnik, Mitchell; Gershwin, M. Eric; Podda, Mauro.

In: Lancet, Vol. 363, No. 9408, 14.02.2004, p. 533-535.

Research output: Contribution to journalArticle

Invernizzi, P, Miozzo, M, Battezzati, PM, Bianchi, I, Grati, FR, Simoni, G, Selmi, C, Watnik, M, Gershwin, ME & Podda, M 2004, 'Frequency of monosomy X in women with primary biliary cirrhosis', Lancet, vol. 363, no. 9408, pp. 533-535. https://doi.org/10.1016/S0140-6736(04)15541-4
Invernizzi P, Miozzo M, Battezzati PM, Bianchi I, Grati FR, Simoni G et al. Frequency of monosomy X in women with primary biliary cirrhosis. Lancet. 2004 Feb 14;363(9408):533-535. https://doi.org/10.1016/S0140-6736(04)15541-4
Invernizzi, Pietro ; Miozzo, Monica ; Battezzati, Pier Maria ; Bianchi, Ilaria ; Grati, Francesca R. ; Simoni, Giuseppe ; Selmi, Carlo ; Watnik, Mitchell ; Gershwin, M. Eric ; Podda, Mauro. / Frequency of monosomy X in women with primary biliary cirrhosis. In: Lancet. 2004 ; Vol. 363, No. 9408. pp. 533-535.
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