Abstract
The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 288-293 |
| Number of pages | 6 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1067 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - May 2006 |
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Keywords
- Atherosclerosis
- Carotid stenosis
- Cytokine
- IL-10
- SNP
- TGF-β1
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Frequency of polymorphisms of signal peptide of TGF-β1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis. / Crivello, Antonio; Giacalone, Antonio; Scola, Letizia; Forte, Giusi Irma; Nuzzo, Domenico; Giacconi, Robertina; Cipriano, Catia; Candore, Giuseppina; Mocchegiani, Eugenio; Romano, Giuseppina Colonna; Lio, Domenico; Caruso, Calogero.
In: Annals of the New York Academy of Sciences, Vol. 1067, No. 1, 05.2006, p. 288-293.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequency of polymorphisms of signal peptide of TGF-β1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis
AU - Crivello, Antonio
AU - Giacalone, Antonio
AU - Scola, Letizia
AU - Forte, Giusi Irma
AU - Nuzzo, Domenico
AU - Giacconi, Robertina
AU - Cipriano, Catia
AU - Candore, Giuseppina
AU - Mocchegiani, Eugenio
AU - Romano, Giuseppina Colonna
AU - Lio, Domenico
AU - Caruso, Calogero
PY - 2006/5
Y1 - 2006/5
N2 - The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.
AB - The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.
KW - Atherosclerosis
KW - Carotid stenosis
KW - Cytokine
KW - IL-10
KW - SNP
KW - TGF-β1
UR - http://www.scopus.com/inward/record.url?scp=33744479988&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33744479988&partnerID=8YFLogxK
U2 - 10.1196/annals.1354.038
DO - 10.1196/annals.1354.038
M3 - Article
C2 - 16804000
AN - SCOPUS:33744479988
VL - 1067
SP - 288
EP - 293
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - 1
ER -