Frequency of polymorphisms of signal peptide of TGF-β1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

Antonio Crivello, Antonio Giacalone, Letizia Scola, Giusi Irma Forte, Domenico Nuzzo, Robertina Giacconi, Catia Cipriano, Giuseppina Candore, Eugenio Mocchegiani, Giuseppina Colonna Romano, Domenico Lio, Calogero Caruso

Research output: Contribution to journalArticle

Abstract

The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.

Original languageEnglish
Pages (from-to)288-293
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1067
Issue number1
DOIs
Publication statusPublished - May 2006

Keywords

  • Atherosclerosis
  • Carotid stenosis
  • Cytokine
  • IL-10
  • SNP
  • TGF-β1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Crivello, A., Giacalone, A., Scola, L., Forte, G. I., Nuzzo, D., Giacconi, R., Cipriano, C., Candore, G., Mocchegiani, E., Romano, G. C., Lio, D., & Caruso, C. (2006). Frequency of polymorphisms of signal peptide of TGF-β1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis. Annals of the New York Academy of Sciences, 1067(1), 288-293. https://doi.org/10.1196/annals.1354.038