Frequency of polymorphisms of signal peptide of TGF-β1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

Antonio Crivello; Antonio Giacalone; Letizia Scola; Giusi Irma Forte; Domenico Nuzzo; Robertina Giacconi; Catia Cipriano; Giuseppina Candore; Eugenio Mocchegiani; Giuseppina Colonna Romano; Domenico Lio; Calogero Caruso

doi:10.1196/annals.1354.038

Frequency of polymorphisms of signal peptide of TGF-β1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

Antonio Crivello, Antonio Giacalone, Letizia Scola, Giusi Irma Forte, Domenico Nuzzo, Robertina Giacconi, Catia Cipriano, Giuseppina Candore, Eugenio Mocchegiani, Giuseppina Colonna Romano, Domenico Lio, Calogero Caruso

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.

Original language	English
Pages (from-to)	288-293
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	1067
Issue number	1
DOIs	https://doi.org/10.1196/annals.1354.038
Publication status	Published - May 2006

Keywords

Atherosclerosis
Carotid stenosis
Cytokine
IL-10
SNP
TGF-β1

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1196/annals.1354.038

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Crivello, A., Giacalone, A., Scola, L., Forte, G. I., Nuzzo, D., Giacconi, R., Cipriano, C., Candore, G., Mocchegiani, E., Romano, G. C., Lio, D., & Caruso, C. (2006). Frequency of polymorphisms of signal peptide of TGF-β1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis. Annals of the New York Academy of Sciences, 1067(1), 288-293. https://doi.org/10.1196/annals.1354.038

Crivello, A, Giacalone, A, Scola, L, Forte, GI, Nuzzo, D, Giacconi, R, Cipriano, C, Candore, G, Mocchegiani, E, Romano, GC, Lio, D & Caruso, C 2006, 'Frequency of polymorphisms of signal peptide of TGF-β1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis', Annals of the New York Academy of Sciences, vol. 1067, no. 1, pp. 288-293. https://doi.org/10.1196/annals.1354.038

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abstract = "The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.",

keywords = "Atherosclerosis, Carotid stenosis, Cytokine, IL-10, SNP, TGF-β1",

author = "Antonio Crivello and Antonio Giacalone and Letizia Scola and Forte, {Giusi Irma} and Domenico Nuzzo and Robertina Giacconi and Catia Cipriano and Giuseppina Candore and Eugenio Mocchegiani and Romano, {Giuseppina Colonna} and Domenico Lio and Calogero Caruso",

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AU - Crivello, Antonio

AU - Giacalone, Antonio

AU - Scola, Letizia

AU - Forte, Giusi Irma

AU - Nuzzo, Domenico

AU - Giacconi, Robertina

AU - Cipriano, Catia

AU - Candore, Giuseppina

AU - Mocchegiani, Eugenio

AU - Romano, Giuseppina Colonna

AU - Lio, Domenico

AU - Caruso, Calogero

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AB - The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.

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KW - Carotid stenosis

KW - Cytokine

KW - IL-10

KW - SNP

KW - TGF-β1

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Frequency of polymorphisms of signal peptide of TGF-β1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

Abstract

Keywords

ASJC Scopus subject areas

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