Frequency of respiratory viruses among patients admitted to 26 Intensive Care Units in seven consecutive winter-spring seasons (2009–2016) in Northern Italy

Research output: Contribution to journalArticle

Abstract

Background The role of respiratory viruses in the etiology of community-acquired pneumonia (CAP) is still debated. The advent of molecular assays has improved the identification of viruses in patients with CAP and according to published studies, viruses account for 11-55% of adult CAP cases. Objectives and study design In the present study, the frequency of respiratory viruses was evaluated in respiratory samples collected from 414 patients with CAP admitted to 26 ICUs in the Lombardy Region (10 million inhabitants) during seven winter-spring seasons (2009–2016). Results In 226 (54.6%) patients one or more respiratory viruses were identified, while 188 (45.4%) patients were negative. A single virus infection was observed in 214/226 (94.7%) patients; while, in 12/226 (5.3%) at least two respiratory viruses were detected. Influenza A was the most common virus in 140/226 patients (61.9%) followed by rhinoviruses (33/226, 14.6%), respiratory syncytial virus (13/226, 5.8%), influenza B virus (9/226, 4.0%), human coronaviruses (9/226, 4.0%), cytomegalovirus (9/226, 4.0%) and human metapneumovirus (1/226, 0.4%). Conclusions Viral infections are present in a consistent proportion of patients admitted to the ICU for CAP. Influenza A and rhinovirus accounted for three-quarters of all CAP in ICU patients. The use of lower respiratory instead of upper respiratory samples might be useful in the diagnosis of viral CAP.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalJournal of Clinical Virology
Volume92
DOIs
Publication statusPublished - Jul 1 2017

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Italy
Intensive Care Units
Pneumonia
Viruses
Rhinovirus
Virus Diseases
Human Influenza
Metapneumovirus
Influenza B virus
Coronavirus
Respiratory Syncytial Viruses
Cytomegalovirus

Keywords

  • CAP
  • lower respiratory tract infection
  • molecular diagnostic
  • respiratory infection
  • respiratory viruses

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

@article{9ab8f44dbb5e4d1683d595bd63b9f071,
title = "Frequency of respiratory viruses among patients admitted to 26 Intensive Care Units in seven consecutive winter-spring seasons (2009–2016) in Northern Italy",
abstract = "Background The role of respiratory viruses in the etiology of community-acquired pneumonia (CAP) is still debated. The advent of molecular assays has improved the identification of viruses in patients with CAP and according to published studies, viruses account for 11-55{\%} of adult CAP cases. Objectives and study design In the present study, the frequency of respiratory viruses was evaluated in respiratory samples collected from 414 patients with CAP admitted to 26 ICUs in the Lombardy Region (10 million inhabitants) during seven winter-spring seasons (2009–2016). Results In 226 (54.6{\%}) patients one or more respiratory viruses were identified, while 188 (45.4{\%}) patients were negative. A single virus infection was observed in 214/226 (94.7{\%}) patients; while, in 12/226 (5.3{\%}) at least two respiratory viruses were detected. Influenza A was the most common virus in 140/226 patients (61.9{\%}) followed by rhinoviruses (33/226, 14.6{\%}), respiratory syncytial virus (13/226, 5.8{\%}), influenza B virus (9/226, 4.0{\%}), human coronaviruses (9/226, 4.0{\%}), cytomegalovirus (9/226, 4.0{\%}) and human metapneumovirus (1/226, 0.4{\%}). Conclusions Viral infections are present in a consistent proportion of patients admitted to the ICU for CAP. Influenza A and rhinovirus accounted for three-quarters of all CAP in ICU patients. The use of lower respiratory instead of upper respiratory samples might be useful in the diagnosis of viral CAP.",
keywords = "CAP, lower respiratory tract infection, molecular diagnostic, respiratory infection, respiratory viruses",
author = "Antonio Piralla and Bianca Mariani and Francesca Rovida and Fausto Baldanti",
year = "2017",
month = "7",
day = "1",
doi = "10.1016/j.jcv.2017.05.004",
language = "English",
volume = "92",
pages = "48--51",
journal = "Journal of Clinical Virology",
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T1 - Frequency of respiratory viruses among patients admitted to 26 Intensive Care Units in seven consecutive winter-spring seasons (2009–2016) in Northern Italy

AU - Piralla, Antonio

AU - Mariani, Bianca

AU - Rovida, Francesca

AU - Baldanti, Fausto

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background The role of respiratory viruses in the etiology of community-acquired pneumonia (CAP) is still debated. The advent of molecular assays has improved the identification of viruses in patients with CAP and according to published studies, viruses account for 11-55% of adult CAP cases. Objectives and study design In the present study, the frequency of respiratory viruses was evaluated in respiratory samples collected from 414 patients with CAP admitted to 26 ICUs in the Lombardy Region (10 million inhabitants) during seven winter-spring seasons (2009–2016). Results In 226 (54.6%) patients one or more respiratory viruses were identified, while 188 (45.4%) patients were negative. A single virus infection was observed in 214/226 (94.7%) patients; while, in 12/226 (5.3%) at least two respiratory viruses were detected. Influenza A was the most common virus in 140/226 patients (61.9%) followed by rhinoviruses (33/226, 14.6%), respiratory syncytial virus (13/226, 5.8%), influenza B virus (9/226, 4.0%), human coronaviruses (9/226, 4.0%), cytomegalovirus (9/226, 4.0%) and human metapneumovirus (1/226, 0.4%). Conclusions Viral infections are present in a consistent proportion of patients admitted to the ICU for CAP. Influenza A and rhinovirus accounted for three-quarters of all CAP in ICU patients. The use of lower respiratory instead of upper respiratory samples might be useful in the diagnosis of viral CAP.

AB - Background The role of respiratory viruses in the etiology of community-acquired pneumonia (CAP) is still debated. The advent of molecular assays has improved the identification of viruses in patients with CAP and according to published studies, viruses account for 11-55% of adult CAP cases. Objectives and study design In the present study, the frequency of respiratory viruses was evaluated in respiratory samples collected from 414 patients with CAP admitted to 26 ICUs in the Lombardy Region (10 million inhabitants) during seven winter-spring seasons (2009–2016). Results In 226 (54.6%) patients one or more respiratory viruses were identified, while 188 (45.4%) patients were negative. A single virus infection was observed in 214/226 (94.7%) patients; while, in 12/226 (5.3%) at least two respiratory viruses were detected. Influenza A was the most common virus in 140/226 patients (61.9%) followed by rhinoviruses (33/226, 14.6%), respiratory syncytial virus (13/226, 5.8%), influenza B virus (9/226, 4.0%), human coronaviruses (9/226, 4.0%), cytomegalovirus (9/226, 4.0%) and human metapneumovirus (1/226, 0.4%). Conclusions Viral infections are present in a consistent proportion of patients admitted to the ICU for CAP. Influenza A and rhinovirus accounted for three-quarters of all CAP in ICU patients. The use of lower respiratory instead of upper respiratory samples might be useful in the diagnosis of viral CAP.

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