Frequent aberrant promoter hypermethylation of O6-methylguanine- DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas

Davide Rossi, Gianluca Gaidano, Annunziata Gloghini, Clara Deambrogi, Silvia Franceschetti, Eva Berra, Michaela Cerri, Chiara Vendramin, Annarita Conconi, Alessandra Viglio, Giuliana Muti, Pierluigi Oreste, Enrica Morra, Marco Paulli, Daniela Capello, Antonino Carbone

Research output: Contribution to journalArticlepeer-review

Abstract

Aberrant promoter hypermethylation is a mechanism of tumour suppressor gene inactivation. We explored aberrant promoter hypermethylation of multiple genes in 88 human immunodeficiency virus (HIV)-non Hodgkin lymphomas (NHL). 25 post-transplant lymphoproliferative disorders (PTLD) and five common variable immunodeficiency (CVI)-related NHL. Twenty-six of 79 (32.9%) HIV-NHL, eight of 14 (57.1%) PTLD and two of five (40.0%) CVI-NHL showed aberrant hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT). Aberrant hypermethylation of death-associated protein-kinase (DAP-K) occurred in 70 of 84 (83.3%) HIV-NHL, 19 of 25 (72.0%) PTLD and three of five (60.0%) CVI-NHL. These data implicate MGMT and DAP-K hypermethylation in lymphomagenesis of immunodeficient hosts. In particular, promoter hypermethylation of DAP-K represents the most frequent molecular alteration yet identified in immunodeficiency-related lymphomas.

Original languageEnglish
Pages (from-to)475-478
Number of pages4
JournalBritish Journal of Haematology
Volume123
Issue number3
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Death associated protein-kinase
  • DNA methylation
  • Immunodeficiency
  • Lymphoma
  • O-methylguanine-DNA methyltransferase

ASJC Scopus subject areas

  • Hematology

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