Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma

G. Zehender, L. Meroni, S. Piconi, C. De Maddalena, C. Parravicini, M. Clerici, A. L. Ridolfo, M. Moroni, M. Galli

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected patients without lymphoma (194 of whom were diagnosed as having AIDS), and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin lymphoma. The frequency of serological reactivity against HTLV antigens was significantly higher in the AIDS patients with lymphoma than in those without (8 of 22, 36.4% vs. 20 of 194, 10.3% - p = 0.0027). One of the HIV-1-positive and none of the HIV-1- negative patients with Hodgkin lymphoma showed anti-HTLV-I/II reactivity. Four of the eight seropositive NHL patients showed antibodies directed against HTLV-II recombinant antigens when tested for serological discrimination in a Western blot assay. A PCR study of PBMCs from the only patient with NHL still alive at the time of the study showed HTLV-II-specific sequences in the genomic DNA. These data suggest that HTLV-H or a closely homologous retrovirus infects a high proportion of patients with AIDS- associated NHL.

Original languageEnglish
Pages (from-to)823-827
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume11
Issue number7
Publication statusPublished - 1995

Fingerprint

Deltaretrovirus Antigens
AIDS-Related Lymphoma
Non-Hodgkin's Lymphoma
Antibodies
HIV-1
Human T-lymphotropic virus 2
HTLV-II Antigens
Hodgkin Disease
HTLV-II Antibodies
Lymphoma
Acquired Immunodeficiency Syndrome
HTLV-I Antibodies
Human T-lymphotropic virus 1
Time and Motion Studies
Retroviridae
Western Blotting

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Zehender, G., Meroni, L., Piconi, S., De Maddalena, C., Parravicini, C., Clerici, M., ... Galli, M. (1995). Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma. AIDS Research and Human Retroviruses, 11(7), 823-827.

Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma. / Zehender, G.; Meroni, L.; Piconi, S.; De Maddalena, C.; Parravicini, C.; Clerici, M.; Ridolfo, A. L.; Moroni, M.; Galli, M.

In: AIDS Research and Human Retroviruses, Vol. 11, No. 7, 1995, p. 823-827.

Research output: Contribution to journalArticle

Zehender, G, Meroni, L, Piconi, S, De Maddalena, C, Parravicini, C, Clerici, M, Ridolfo, AL, Moroni, M & Galli, M 1995, 'Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma', AIDS Research and Human Retroviruses, vol. 11, no. 7, pp. 823-827.
Zehender, G. ; Meroni, L. ; Piconi, S. ; De Maddalena, C. ; Parravicini, C. ; Clerici, M. ; Ridolfo, A. L. ; Moroni, M. ; Galli, M. / Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma. In: AIDS Research and Human Retroviruses. 1995 ; Vol. 11, No. 7. pp. 823-827.
@article{2f9e7e0b2660401289681deb100f2e00,
title = "Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma",
abstract = "We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected patients without lymphoma (194 of whom were diagnosed as having AIDS), and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin lymphoma. The frequency of serological reactivity against HTLV antigens was significantly higher in the AIDS patients with lymphoma than in those without (8 of 22, 36.4{\%} vs. 20 of 194, 10.3{\%} - p = 0.0027). One of the HIV-1-positive and none of the HIV-1- negative patients with Hodgkin lymphoma showed anti-HTLV-I/II reactivity. Four of the eight seropositive NHL patients showed antibodies directed against HTLV-II recombinant antigens when tested for serological discrimination in a Western blot assay. A PCR study of PBMCs from the only patient with NHL still alive at the time of the study showed HTLV-II-specific sequences in the genomic DNA. These data suggest that HTLV-H or a closely homologous retrovirus infects a high proportion of patients with AIDS- associated NHL.",
author = "G. Zehender and L. Meroni and S. Piconi and {De Maddalena}, C. and C. Parravicini and M. Clerici and Ridolfo, {A. L.} and M. Moroni and M. Galli",
year = "1995",
language = "English",
volume = "11",
pages = "823--827",
journal = "AIDS Research and Human Retroviruses",
issn = "0889-2229",
publisher = "Mary Ann Liebert Inc.",
number = "7",

}

TY - JOUR

T1 - Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma

AU - Zehender, G.

AU - Meroni, L.

AU - Piconi, S.

AU - De Maddalena, C.

AU - Parravicini, C.

AU - Clerici, M.

AU - Ridolfo, A. L.

AU - Moroni, M.

AU - Galli, M.

PY - 1995

Y1 - 1995

N2 - We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected patients without lymphoma (194 of whom were diagnosed as having AIDS), and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin lymphoma. The frequency of serological reactivity against HTLV antigens was significantly higher in the AIDS patients with lymphoma than in those without (8 of 22, 36.4% vs. 20 of 194, 10.3% - p = 0.0027). One of the HIV-1-positive and none of the HIV-1- negative patients with Hodgkin lymphoma showed anti-HTLV-I/II reactivity. Four of the eight seropositive NHL patients showed antibodies directed against HTLV-II recombinant antigens when tested for serological discrimination in a Western blot assay. A PCR study of PBMCs from the only patient with NHL still alive at the time of the study showed HTLV-II-specific sequences in the genomic DNA. These data suggest that HTLV-H or a closely homologous retrovirus infects a high proportion of patients with AIDS- associated NHL.

AB - We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected patients without lymphoma (194 of whom were diagnosed as having AIDS), and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin lymphoma. The frequency of serological reactivity against HTLV antigens was significantly higher in the AIDS patients with lymphoma than in those without (8 of 22, 36.4% vs. 20 of 194, 10.3% - p = 0.0027). One of the HIV-1-positive and none of the HIV-1- negative patients with Hodgkin lymphoma showed anti-HTLV-I/II reactivity. Four of the eight seropositive NHL patients showed antibodies directed against HTLV-II recombinant antigens when tested for serological discrimination in a Western blot assay. A PCR study of PBMCs from the only patient with NHL still alive at the time of the study showed HTLV-II-specific sequences in the genomic DNA. These data suggest that HTLV-H or a closely homologous retrovirus infects a high proportion of patients with AIDS- associated NHL.

UR - http://www.scopus.com/inward/record.url?scp=0028984814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028984814&partnerID=8YFLogxK

M3 - Article

C2 - 7546909

AN - SCOPUS:0028984814

VL - 11

SP - 823

EP - 827

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 7

ER -