Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma

G. Zehender, L. Meroni, S. Piconi, C. De Maddalena, C. Parravicini, M. Clerici, A. L. Ridolfo, M. Moroni, M. Galli

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected patients without lymphoma (194 of whom were diagnosed as having AIDS), and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin lymphoma. The frequency of serological reactivity against HTLV antigens was significantly higher in the AIDS patients with lymphoma than in those without (8 of 22, 36.4% vs. 20 of 194, 10.3% - p = 0.0027). One of the HIV-1-positive and none of the HIV-1- negative patients with Hodgkin lymphoma showed anti-HTLV-I/II reactivity. Four of the eight seropositive NHL patients showed antibodies directed against HTLV-II recombinant antigens when tested for serological discrimination in a Western blot assay. A PCR study of PBMCs from the only patient with NHL still alive at the time of the study showed HTLV-II-specific sequences in the genomic DNA. These data suggest that HTLV-H or a closely homologous retrovirus infects a high proportion of patients with AIDS- associated NHL.

Original languageEnglish
Pages (from-to)823-827
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume11
Issue number7
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Immunology
  • Virology

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