Frequent expression of the NPM-ALK chimeric fusion protein in anaplastic large-cell lymphoma, lympho-histiocytic type

Stefane A. Pileri, Karen Pulford, Shigeo Mori, David Y. Mason, Elena Sabattini, Giovanna Roncador, Milena Piccioli, Claudio Ceccarelli, Pier Paolo Piccaluga, Donatella Santini, Ornella Leone, Harald Stein, Brunangelo Falini

Research output: Contribution to journalArticlepeer-review

Abstract

The revised European-American lymphoma classification recognizes a subtype of anaplastic large-cell lymphoma (ALCL), termed lympho-histiocytic because of its peculiar cytological composition. As in the case of classical ALCL, this tumor usually occurs in young patients and shows an excellent response to chemotherapy, but some authors have suggested that in reality this is a nonanaplastic T-cell lymphoma rich in histiocytes. In this paper, we show that three of five cases of lympho-histiocytic ALCL stain with anti- ALK antibodies and can therefore be presumed to express the chimeric NPM/ALK protein secondary to (2;5) translocation. These findings further support the inclusion of this as a type of ALCL and not among the nonanaplastic peripheral T-cell lymphomas. Furthermore, they indicate that staining for ALK proteins is a powerful tool for the diagnosis of lympho-histiocytic ALCL, the recognition of which may be difficult on morphological grounds.

Original languageEnglish
Pages (from-to)1207-1211
Number of pages5
JournalAmerican Journal of Pathology
Volume150
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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