Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1-18 |
| Number of pages | 18 |
| Journal | Biochimica et Biophysica Acta - Reviews on Cancer |
| Volume | 1867 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2017 |
Keywords
- Cancer-associated fibroblasts
- Cell-cell communications
- Colorectal cancer
- Immune cells
- Stromal cells
- Tumour microenvironment
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Friend or foe?: The tumour microenvironment dilemma in colorectal cancer. / Colangelo, Tommaso; Polcaro, G.; Muccillo, L. et al.
In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1867, No. 1, 2017, p. 1-18.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Friend or foe?: The tumour microenvironment dilemma in colorectal cancer
AU - Colangelo, Tommaso
AU - Polcaro, G.
AU - Muccillo, L.
AU - D'Agostino, G.
AU - Rosato, V.
AU - Ziccardi, P.
AU - Lupo, A.
AU - Mazzoccoli, G.
AU - Sabatino, Lina
AU - Colantuoni, Vittorio
N1 - Export Date: 22 March 2017 CODEN: BBACE Correspondence Address: Mazzoccoli, G.; IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”, San Giovanni Rotondo (FG), Italy References: Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation (2011) Cell, 144, pp. 646-674; Quail, F.D., Joyce, J.A., Microenvironmental regulation of tumor progression and metastasis (2013) Nat. Med., 19. , e1423; Fearon, E.R., Vogelstein, B., A genetic model for colorectal tumorigenesis (1990) Cell, 61, pp. 759-767; Fearon, E.R., Molecular genetics of colorectal cancer (2011) Annu. Rev. Pathol., 6, pp. 479-507; Cunningham, D., Atkin, W., Lenz, H.J., Lynch, H.T., Minsky, B., Nordlinger, B., Starling, N., Colorectal cancer (2010) Lancet, 375, pp. 1030-1047; Tenesa, A., Dunlop, M.G., New insights into the aetiology of colorectal cancer from genome-wide association studies (2009) Nat. Rev. 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PY - 2017
Y1 - 2017
N2 - The network of bidirectional homotypic and heterotypic interactions established among parenchymal tumour cells and surrounding mesenchymal stromal cells generates the tumour microenvironment (TME). These intricate crosstalks elicit both beneficial and adverse effects on tumour initiation and progression unbalancing the signals and responses from the neighbouring cells. Here, we highlight the structure, activities and evolution of TME cells considering a novel colorectal cancer (CRC) classification based on differential stromal composition and gene expression profiles. In this scenario, we scrutinise the molecular pathways that either change or become corrupted during CRC development and their relative prognostic value. Finally, we survey the therapeutic molecules directed against TME components currently available in clinical trials as well as those with stronger potential in preclinical studies. Elucidation of dynamic variations in the CRC TME cell composition and their relative contribution could provide novel diagnostic or prognostic biomarkers and allow more personalised therapeutic strategies. © 2016
AB - The network of bidirectional homotypic and heterotypic interactions established among parenchymal tumour cells and surrounding mesenchymal stromal cells generates the tumour microenvironment (TME). These intricate crosstalks elicit both beneficial and adverse effects on tumour initiation and progression unbalancing the signals and responses from the neighbouring cells. Here, we highlight the structure, activities and evolution of TME cells considering a novel colorectal cancer (CRC) classification based on differential stromal composition and gene expression profiles. In this scenario, we scrutinise the molecular pathways that either change or become corrupted during CRC development and their relative prognostic value. Finally, we survey the therapeutic molecules directed against TME components currently available in clinical trials as well as those with stronger potential in preclinical studies. Elucidation of dynamic variations in the CRC TME cell composition and their relative contribution could provide novel diagnostic or prognostic biomarkers and allow more personalised therapeutic strategies. © 2016
KW - Cancer-associated fibroblasts
KW - Cell-cell communications
KW - Colorectal cancer
KW - Immune cells
KW - Stromal cells
KW - Tumour microenvironment
U2 - 10.1016/j.bbcan.2016.11.001
DO - 10.1016/j.bbcan.2016.11.001
M3 - Article
VL - 1867
SP - 1
EP - 18
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
SN - 0304-419X
IS - 1
ER -