From 3-port to new Laparoendoscopic single-site (LESS) cholecystectomy: A critical analysis of available evidence

Alessandro Puzziello, Giulio Orlando, Claudio Siani, Rita Gervasi, Maria A. Lerose, Ada M. Lucisano, Giuseppina Vescio, Rosario Sacco

Research output: Contribution to journalReview articlepeer-review


In recent years, laparoendoscopic single-site surgery (LESS) has gained greater interest and diffusion for the treatment of gallstones. This critical review aims to evaluate the feasibility and safety of LESS cholecystectomy versus the 3-port technique (TPT) through a comparative analysis of 5 parameters: mean operative time, intraoperative and postoperative complications, conversion to open, conversion to the 4-trocar technique and postoperative hospital stay. The authors performed a systematic search of the medical literature through a search of PubMed and Ovid EMBASE. Inclusion criteria were as follows: publication date between January 1, 2005, and December 31, 2010; English or Italian language; human participants and series of 20 operations or more. There were 5 manuscripts meeting the inclusion criteria for TPT and 23 for LESS. Only one prospective randomized controlled trial comparing TPT and LESS was identified. Operative time is significantly longer in the single-incision group. Complications and conversion rates to the 4-port technique are higher in LESS. Postoperative hospital stay is similar in the 2 groups. Rate of conversion to open is higher in TPT. Despite the number of publications on LESS cholecystectomy, the vast majority of data available in the literature are from small case series without any comparative data. Although LESS cholecystectomy is a fashionable technique there are few data available for an evidence-based determination as to the real benefits of this technique. Well-designed comparative studies are suggested to validate the clinical benefits and ensure that there are no new complications or added costs associated with the new technique.

Original languageEnglish
Pages (from-to)364-369
Number of pages6
JournalSurgical Innovation
Issue number4
Publication statusPublished - Dec 2012


  • 3 port
  • laparoscopic cholecystectomy
  • LESS

ASJC Scopus subject areas

  • Surgery


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