Velazquez showed to know the entity of thumb osteoarthritis by finely describing it in one of his paintings. The concepts of anatomical damage, loss of strenght, and functional impairment are transmitted to the observer.
Villafane, J. H., Cantero-Tellez, R., Negrini, S., & Berjano, P. (2017). From art to science: the functional damage due to thumb osteoarthritis finely described by Velazquez 300 years before its clinical description. Reumatismo, 69(3), 137-139. https://doi.org/10.4081/reumatismo.2017.1009