From benzalkonium chloride-preserved Latanoprost to Polyquad-preserved Travoprost: A 6-month study on ocular surface safety and tolerability

Background: To evaluate the safety and tolerability of Polyquad-preserved Travoprost (PQ-Travoprost) in patients previously treated with benzalkonium chloride (BAK)-preserved Latanoprost.Methods: Cohort 6-month study on open-angle glaucoma or ocular hypertension patients. Complete ophthalmic examination, intraocular pressure (IOP) measurement and ocular surface status (tear film break-up time [TF-BUT], corneal staining and ocular surface disease index [OSDI]) were evaluated at baseline and 6 months later.Results: A total of 44 patients were enrolled. Median (interquartile range [IQR]) baseline IOP was 18 (15.5-21) and 16 (14-17) mmHg (p <0.0001) after 6 months. At baseline, 18 (40.9%) patients presented an IOP of <18 mmHg, 11 (25%) <16 mmHg, 2 (4.3%) <14 mmHg and 1 (2.3%) <12 mmHg; 6 months later the proportions were 36 (81.8%) (p <0.0001), 21 (47.7%) (p = 0.00075), 8 (18.2%) (p = 0.0143) and 6 (13.6%) (p = 0.0253). Concerning safety, TF-BUT improved from 8 [IQR 6-10] to 10 [IQR 8-12] s (p <0.0001). No eye developed corneal staining; punctate keratitis was absent in 13 (29.5%) patients at baseline and in 31 (70.4%) after 6 months (p <0.001). OSDI changed from 16 (10-30) to 9 (2-20).Conclusions: No patient treated with PQ-Travoprost developed ocular surface disease after 6 months of monotherapy, whereas many patients reached a good IOP control with lower IOP values. Ocular surface status statistically improved when examined by TF-BUT and corneal staining.