From chemotherapy to target therapies associated with radiation in the treatment of NSCLC: a durable marriage?

Filippo Alongi, Stefano Arcangeli, Sara Ramella, Niccolò Giaj-Levra, Paolo Borghetti, Rolando D’angelillo, Francesco Ricchetti, Marta Maddalo, Rosario Mazzola, Marco Trovò, Elvio Russi, Stefano Maria Magrini, the behalf of Associazione Italiana Radioterapia Oncologica (AIRO) on the behalf of Associazione Italiana Radioterapia Oncologica (AIRO)

Research output: Contribution to journalReview article

Abstract

Introduction: The integration between radiotherapy and drugs, from chemotherapy to recently available target therapies, continues to have a relevant role in the treatment of locally advanced and metastatic Non-small cell lung cancer (NSCLC). Aim of the present review is to evaluate the promising and emerging application of the best interaction between new drugs and new modalities of radiotherapy. Areas covered: We searched Medline, Google Scholar, PubMed, ProQuest Dissertation, and Theses databases for reports published in English. A study was included when it reported on cancer-related radiotherapy and included patients with NSCLC treated with chemo and/or target therapies. Review articles were excluded from the analysis. Expert commentary: Chemo-radiotherapy still represents the standard of choice in locally advanced NSCLC, while to date the addition of target therapies to chemo-radiotherapy did not demonstrate any robust advantage in this stage of disease. Considering the absence of randomized controlled trials, the role of target therapies in early stage adjuvant NSCLC is not yet recommended in clinical practice. On the contrary, in the setting of oligometastatic and oligoprogressive disease, new molecules demonstrated to be safe and effective, opening to a promising and emerging application of the best interaction between new drugs and new modalities of radiotherapy.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalExpert Review of Anticancer Therapy
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

Keywords

  • early stage
  • locally advanced
  • Lung cancer
  • oligometastatic
  • radiotherapy
  • target therapies

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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  • Cite this

    Alongi, F., Arcangeli, S., Ramella, S., Giaj-Levra, N., Borghetti, P., D’angelillo, R., Ricchetti, F., Maddalo, M., Mazzola, R., Trovò, M., Russi, E., Magrini, S. M., & on the behalf of Associazione Italiana Radioterapia Oncologica (AIRO), T. B. O. A. I. R. O. AIRO. (2017). From chemotherapy to target therapies associated with radiation in the treatment of NSCLC: a durable marriage? Expert Review of Anticancer Therapy, 17(2), 157-165. https://doi.org/10.1080/14737140.2017.1273111