From erythema multiforme to toxic epidermal necrolysis. Same spectrum or different diseases?

C. Tomasini, F. Derlino, P. Quaglino, M. Caproni, G. Borroni

Research output: Contribution to journalArticle

Abstract

Erythema multiforme (EM), Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute bullous disorders associated to different prognosis, mainly due to infections and drugs. More in particular EM in more than 90% is caused by infections (especially Herpes virus infection), while, on the other hand SJS and TEN are referable in more than 95% of cases to drugs. Distinction among these three forms is often controversal and still debated. An attempt to distinguish these forms has been possible mainly according to anamnesis, clinical presentation (morphology, involved sites, extension of lesions) and pathogenetic mechanisms, being on the contrary more difficult from an histopathological point of view. Nowadays a clear diagnosis and a distinction from other life-threatening diseases is possible with the integration of all the mentioned aspects. Moreover, this recognition should be as early as possible in order to perform a prognostic evaluation of the case and to start supportive cares and therapies as soon as possible.

Original languageEnglish
Pages (from-to)243-261
Number of pages19
JournalGiornale Italiano di Dermatologia e Venereologia
Volume149
Issue number2
Publication statusPublished - 2014

Keywords

  • Biopsy
  • Drugs
  • Erythema multiforme
  • Stevens-Johnson Syndrome

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'From erythema multiforme to toxic epidermal necrolysis. Same spectrum or different diseases?'. Together they form a unique fingerprint.

  • Cite this

    Tomasini, C., Derlino, F., Quaglino, P., Caproni, M., & Borroni, G. (2014). From erythema multiforme to toxic epidermal necrolysis. Same spectrum or different diseases? Giornale Italiano di Dermatologia e Venereologia, 149(2), 243-261.