From germinal matrix to cerebellar haemorrhage

Monica Fumagalli, Laura Bassi, Ida Sirgiovanni, Fabio Mosca, Andrea Sannia, Luca A. Ramenghi

Research output: Contribution to journalArticlepeer-review

Abstract

For many years cerebellar development after preterm birth has been poorly investigated and has been studied without taking germinal matrix-intraventricular haemorrhage into account. Advanced neuroimaging techniques like magnetic resonance imaging, as well as the use of various acoustic windows (mastoid fontanelle, occipital foramen) have allowed for in vivo diagnosis of acquired focal haemorrhagic lesions in the cerebellum of very preterm babies. The vulnerability of the cerebellum also seems to be related to specific gestational ages, i.e., between 23 and 27 weeks, when rapid growth in cerebellar volume occurs and at a much faster rate than mean brain volume increase. In this paper, the contribution of the cerebellum in long-term motor cognitive, learning and behavioural functions, including psychiatric ones, is discussed.

Original languageEnglish
Pages (from-to)2280-2285
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume28
DOIs
Publication statusPublished - Nov 20 2015

Keywords

  • Brain development
  • cerebellar haemorrhages
  • cerebellar lesions
  • ELBW
  • GMH-IVH
  • pons development

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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