From hepatitis C virus infection to B-cell lymphoma

L. Couronné, E. Bachy, S. Roulland, B. Nadel, F. Davi, M. Armand, D. Canioni, J. M. Michot, C. Visco, L. Arcaini, C. Besson, O. Hermine

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

In addition to liver disorders, hepatitis C virus (HCV) is also associated with extrahepatic immune manifestations and B-cell non- Hodgkin lymphoma (NHL), especially marginal zone lymphoma, de novo or transformed diffuse large B-cell lymphoma and to a lesser extent, follicular lymphoma. Epidemiological data and clinical observations argue for an association between HCV and lymphoproliferative disorders. The causative role of HCV in NHL has been further supported by the response to antiviral therapy. Pathophysiological processes at stake leading from HCV infection to overt lymphoma still need to be further elucidated. Based on reported biological studies, several mechanisms of transformation seem however to emerge. A strong body of evidence supports the hypothesis of an indirect transformation mechanism by which sustained antigenic stimulation leads from oligoclonal to monoclonal expansion and sometimes to frank lymphoma, mostly of marginal zone subtype. By infecting lymphocytes, HCV could play a direct role in cellular transformation, particularly in de novo large B-cell lymphoma. Finally, HCV is associated with follicular lymphoma in a subset of patients. In this setting, it may be hypothesized that inflammatory cytokines stimulate proliferation and transformation of IgH-BCL2 clones that are increased during chronic HCV infection. Unraveling the pathogenesis of HCV-related B-cell lymphoproliferation is of prime importance to optimize therapeutic strategies, especially with the recent development of new direct-acting antiviral drugs.

Original languageEnglish
Article numbermdx635
Pages (from-to)92-100
Number of pages9
JournalAnnals of Oncology
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

B-Cell Lymphoma
Virus Diseases
Hepacivirus
Lymphoma
Follicular Lymphoma
Non-Hodgkin's Lymphoma
Antiviral Agents
Lymphoproliferative Disorders
Lymphoma, Large B-Cell, Diffuse
Chronic Hepatitis C
B-Lymphocytes
Clone Cells
Lymphocytes
Cytokines
Liver
Therapeutics

Keywords

  • Hepatitis C virus
  • Models of transformation
  • Non-Hodgkin lymphoma
  • Oncogenesis

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Couronné, L., Bachy, E., Roulland, S., Nadel, B., Davi, F., Armand, M., ... Hermine, O. (2018). From hepatitis C virus infection to B-cell lymphoma. Annals of Oncology, 29(1), 92-100. [mdx635]. https://doi.org/10.1093/annonc/mdx635

From hepatitis C virus infection to B-cell lymphoma. / Couronné, L.; Bachy, E.; Roulland, S.; Nadel, B.; Davi, F.; Armand, M.; Canioni, D.; Michot, J. M.; Visco, C.; Arcaini, L.; Besson, C.; Hermine, O.

In: Annals of Oncology, Vol. 29, No. 1, mdx635, 01.01.2018, p. 92-100.

Research output: Contribution to journalReview article

Couronné, L, Bachy, E, Roulland, S, Nadel, B, Davi, F, Armand, M, Canioni, D, Michot, JM, Visco, C, Arcaini, L, Besson, C & Hermine, O 2018, 'From hepatitis C virus infection to B-cell lymphoma' Annals of Oncology, vol. 29, no. 1, mdx635, pp. 92-100. https://doi.org/10.1093/annonc/mdx635
Couronné L, Bachy E, Roulland S, Nadel B, Davi F, Armand M et al. From hepatitis C virus infection to B-cell lymphoma. Annals of Oncology. 2018 Jan 1;29(1):92-100. mdx635. https://doi.org/10.1093/annonc/mdx635
Couronné, L. ; Bachy, E. ; Roulland, S. ; Nadel, B. ; Davi, F. ; Armand, M. ; Canioni, D. ; Michot, J. M. ; Visco, C. ; Arcaini, L. ; Besson, C. ; Hermine, O. / From hepatitis C virus infection to B-cell lymphoma. In: Annals of Oncology. 2018 ; Vol. 29, No. 1. pp. 92-100.
@article{e5d4a812a5f242a584e6dfd2d3f06e64,
title = "From hepatitis C virus infection to B-cell lymphoma",
abstract = "In addition to liver disorders, hepatitis C virus (HCV) is also associated with extrahepatic immune manifestations and B-cell non- Hodgkin lymphoma (NHL), especially marginal zone lymphoma, de novo or transformed diffuse large B-cell lymphoma and to a lesser extent, follicular lymphoma. Epidemiological data and clinical observations argue for an association between HCV and lymphoproliferative disorders. The causative role of HCV in NHL has been further supported by the response to antiviral therapy. Pathophysiological processes at stake leading from HCV infection to overt lymphoma still need to be further elucidated. Based on reported biological studies, several mechanisms of transformation seem however to emerge. A strong body of evidence supports the hypothesis of an indirect transformation mechanism by which sustained antigenic stimulation leads from oligoclonal to monoclonal expansion and sometimes to frank lymphoma, mostly of marginal zone subtype. By infecting lymphocytes, HCV could play a direct role in cellular transformation, particularly in de novo large B-cell lymphoma. Finally, HCV is associated with follicular lymphoma in a subset of patients. In this setting, it may be hypothesized that inflammatory cytokines stimulate proliferation and transformation of IgH-BCL2 clones that are increased during chronic HCV infection. Unraveling the pathogenesis of HCV-related B-cell lymphoproliferation is of prime importance to optimize therapeutic strategies, especially with the recent development of new direct-acting antiviral drugs.",
keywords = "Hepatitis C virus, Models of transformation, Non-Hodgkin lymphoma, Oncogenesis",
author = "L. Couronn{\'e} and E. Bachy and S. Roulland and B. Nadel and F. Davi and M. Armand and D. Canioni and Michot, {J. M.} and C. Visco and L. Arcaini and C. Besson and O. Hermine",
year = "2018",
month = "1",
day = "1",
doi = "10.1093/annonc/mdx635",
language = "English",
volume = "29",
pages = "92--100",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "NLM (Medline)",
number = "1",

}

TY - JOUR

T1 - From hepatitis C virus infection to B-cell lymphoma

AU - Couronné, L.

AU - Bachy, E.

AU - Roulland, S.

AU - Nadel, B.

AU - Davi, F.

AU - Armand, M.

AU - Canioni, D.

AU - Michot, J. M.

AU - Visco, C.

AU - Arcaini, L.

AU - Besson, C.

AU - Hermine, O.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In addition to liver disorders, hepatitis C virus (HCV) is also associated with extrahepatic immune manifestations and B-cell non- Hodgkin lymphoma (NHL), especially marginal zone lymphoma, de novo or transformed diffuse large B-cell lymphoma and to a lesser extent, follicular lymphoma. Epidemiological data and clinical observations argue for an association between HCV and lymphoproliferative disorders. The causative role of HCV in NHL has been further supported by the response to antiviral therapy. Pathophysiological processes at stake leading from HCV infection to overt lymphoma still need to be further elucidated. Based on reported biological studies, several mechanisms of transformation seem however to emerge. A strong body of evidence supports the hypothesis of an indirect transformation mechanism by which sustained antigenic stimulation leads from oligoclonal to monoclonal expansion and sometimes to frank lymphoma, mostly of marginal zone subtype. By infecting lymphocytes, HCV could play a direct role in cellular transformation, particularly in de novo large B-cell lymphoma. Finally, HCV is associated with follicular lymphoma in a subset of patients. In this setting, it may be hypothesized that inflammatory cytokines stimulate proliferation and transformation of IgH-BCL2 clones that are increased during chronic HCV infection. Unraveling the pathogenesis of HCV-related B-cell lymphoproliferation is of prime importance to optimize therapeutic strategies, especially with the recent development of new direct-acting antiviral drugs.

AB - In addition to liver disorders, hepatitis C virus (HCV) is also associated with extrahepatic immune manifestations and B-cell non- Hodgkin lymphoma (NHL), especially marginal zone lymphoma, de novo or transformed diffuse large B-cell lymphoma and to a lesser extent, follicular lymphoma. Epidemiological data and clinical observations argue for an association between HCV and lymphoproliferative disorders. The causative role of HCV in NHL has been further supported by the response to antiviral therapy. Pathophysiological processes at stake leading from HCV infection to overt lymphoma still need to be further elucidated. Based on reported biological studies, several mechanisms of transformation seem however to emerge. A strong body of evidence supports the hypothesis of an indirect transformation mechanism by which sustained antigenic stimulation leads from oligoclonal to monoclonal expansion and sometimes to frank lymphoma, mostly of marginal zone subtype. By infecting lymphocytes, HCV could play a direct role in cellular transformation, particularly in de novo large B-cell lymphoma. Finally, HCV is associated with follicular lymphoma in a subset of patients. In this setting, it may be hypothesized that inflammatory cytokines stimulate proliferation and transformation of IgH-BCL2 clones that are increased during chronic HCV infection. Unraveling the pathogenesis of HCV-related B-cell lymphoproliferation is of prime importance to optimize therapeutic strategies, especially with the recent development of new direct-acting antiviral drugs.

KW - Hepatitis C virus

KW - Models of transformation

KW - Non-Hodgkin lymphoma

KW - Oncogenesis

UR - http://www.scopus.com/inward/record.url?scp=85041207893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041207893&partnerID=8YFLogxK

U2 - 10.1093/annonc/mdx635

DO - 10.1093/annonc/mdx635

M3 - Review article

VL - 29

SP - 92

EP - 100

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 1

M1 - mdx635

ER -