Abstract
| Original language | English |
|---|---|
| Article number | 1946 |
| Journal | Frontiers in Immunology |
| Volume | 8 |
| DOIs | |
| Publication status | Published - 2018 |
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From human Megakaryocytes to platelets: Effects of aspirin on high-mobility group Box 1/receptor for advanced glycation end products axis. / Mardente, S; Mari, Emanuela; Massimi, I; Tafani, M; Guerriero, R; Morsilli, O; Pulcinelli, FM; Bianchi, ME; Zicari, Alessandra.
In: Frontiers in Immunology, Vol. 8, 1946, 2018.Research output: Contribution to journal › Article
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TY - JOUR
T1 - From human Megakaryocytes to platelets: Effects of aspirin on high-mobility group Box 1/receptor for advanced glycation end products axis
AU - Mardente, S
AU - Mari, Emanuela
AU - Massimi, I
AU - Tafani, M
AU - Guerriero, R
AU - Morsilli, O
AU - Pulcinelli, FM
AU - Bianchi, ME
AU - Zicari, Alessandra
PY - 2018
Y1 - 2018
N2 - Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in supernatants of in vitro differentiated MKs and in a megakaryoblastic cell line (DAMI cells). Aspirin "in vivo" and "in vitro" not only reduces HMGB1 and receptor for advanced glycation end products expression on MKs and PLTs but also drives the movement of HMGB1 from MKs into PLTs and PLT-derived MV. These findings suggest that consumption of low doses of aspirin reduces the risk of atherosclerosis complications as well as reducing PLT aggregation by the inhibition of COX-1. © 2018 Mardente, Mari, Massimi, Tafani, Guerriero, Morsilli, Pulcinelli, Bianchi and Zicari.
AB - Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in supernatants of in vitro differentiated MKs and in a megakaryoblastic cell line (DAMI cells). Aspirin "in vivo" and "in vitro" not only reduces HMGB1 and receptor for advanced glycation end products expression on MKs and PLTs but also drives the movement of HMGB1 from MKs into PLTs and PLT-derived MV. These findings suggest that consumption of low doses of aspirin reduces the risk of atherosclerosis complications as well as reducing PLT aggregation by the inhibition of COX-1. © 2018 Mardente, Mari, Massimi, Tafani, Guerriero, Morsilli, Pulcinelli, Bianchi and Zicari.
U2 - 10.3389/fimmu.2017.01946
DO - 10.3389/fimmu.2017.01946
M3 - Article
VL - 8
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 1946
ER -