From interconnection between genes and microenvironment to novel immunotherapeutic approaches in upper gastro-intestinal cancers—A multidisciplinary perspective

Giulia Accordino, Sara Lettieri, Chandra Bortolotto, Silvia Benvenuti, Anna Gallotti, Elisabetta Gattoni, Francesco Agustoni, Emma Pozzi, Pietro Rinaldi, Cristiano Primiceri, Patrizia Morbini, Andrea Lancia, Giulia Maria Stella

Research output: Contribution to journalReview article

Abstract

Despite the progress during the last decade, patients with advanced gastric and esophageal cancers still have poor prognosis. Finding optimal therapeutic strategies represents an unmet need in this field. Several prognostic and predictive factors have been evaluated and may guide clinicians in choosing a tailored treatment. Data from large studies investigating the role of immunotherapy in gastrointestinal cancers are promising but further investigations are necessary to better select those patients who can mostly benefit from these novel therapies. This review will focus on the treatment of metastatic esophageal and gastric cancer. We will review the standard of care and the role of novel therapies such as immunotherapies and CAR-T. Moreover, we will focus on the analysis of potential predictive biomarkers such as Modify as: Microsatellite Instability (MSI) and PD-L1, which may lead to treatment personalization and improved treatment outcomes. A multidisciplinary point of view is mandatory to generate an integrated approach to properly exploit these novel antiproliferative agents.

Original languageEnglish
Article number2105
Pages (from-to)1-29
Number of pages29
JournalCancers
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Esophageal cancer
  • Gastric cancer
  • Genetics
  • Immunotherapy
  • Multidisciplinary

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'From interconnection between genes and microenvironment to novel immunotherapeutic approaches in upper gastro-intestinal cancers—A multidisciplinary perspective'. Together they form a unique fingerprint.

  • Cite this