From lipid retention to immune-mediate inflammation and associated angiogenesis in the pathogenesis of atherosclerosis

Ammara Usman, Domenico Ribatti, Umar Sadat, Jonathan H. Gillard

Research output: Contribution to journalArticle

Abstract

Atherosclerosis is a leading cause of mortality and long-term morbidity worldwide. It is a lipoprotein- driven disease that leads to plaque formation at focal areas in the arterial blood vessels through intimal inflammation, necrosis, fibrosis, and calcification. Adventitial and intimal angiogenesis contributes to the progression of intimal hyperplasia and the development of a necrotic core. The volatile nature of an atheromatous plaque is responsible for approximately 60% of symptomatic carotid artery diseases and about 75% of acute coronary events. In this review the pathogenesis of atherosclerosis is discussed from the initial step of lipid retention to advanced stages of immune-mediate inflammation and associated angiogenesis. Mechanisms of plaque rupture are also discussed.

Original languageEnglish
Pages (from-to)739-749
Number of pages11
JournalJournal of Atherosclerosis and Thrombosis
Volume22
Issue number8
DOIs
Publication statusPublished - Aug 26 2015

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Inflammation
  • Lipid
  • Myocardial infarction
  • Plaque
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

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