From low hematocrit physiology to isovolemic hemodilution

G. Oriani, C. Sacchi, B. Borghi

Research output: Contribution to journalArticlepeer-review


The aim of this study, starting from some concepts of physiology, was to deal with the ever growing question of intentional anemia. Physiology suitably expresses the linear relationship between hematocrit and blood fluidity, and at the same time explains how viscosity and aggreability are important co-factors in the circulation, in disease and in thromboembolic complications. The need to understand how a low hematocrit level, compared to the volemia, is a fundamental requirement in surgery, and even more so in surgery with a high risk of embolism, like orthopedic traumatology surgery. Normovolemic hemodilution was analyzed both for the risks it involves and for how much if sticks to the changes induced by a similar situation on the various organs and apparatus. The authors, based on their experience in the field of anesthesiology, propose an operating schedule to safely perform intentional normovolemic hemodilution, describing the preoperative, intraoperative and finally the postoperative period. In conclusion, the authors advocate a wider use of this technique, confirming its safety in relation to volemia.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalInternational Journal of Artificial Organs
Issue number3
Publication statusPublished - 1995


  • Hemodilution
  • Low hematocrit
  • Volemia

ASJC Scopus subject areas

  • Biophysics


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